C-C motif chemokine ligand 8

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30801661 HDF Human NO
31184599 WI-38 YES
31424120 Primary cytotrophoblast cells derived from placenta Mouse NO
32023351 Primary bone cells derived from bone marrow Mouse NO
32075966 IMR-90 Human YES

GO terms:

Biological Process:
monocyte chemotaxis [GO:0002548],
positive regulation of leukocyte migration [GO:0002687],
protein phosphorylation [GO:0006468],
calcium ion transport [GO:0006816],
cellular calcium ion homeostasis [GO:0006874],
exocytosis [GO:0006887],
chemotaxis [GO:0006935],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
cell-cell signaling [GO:0007267],
response to virus [GO:0009615],
neutrophil chemotaxis [GO:0030593],
positive regulation of GTPase activity [GO:0043547],
negative regulation by host of viral genome replication [GO:0044828],
eosinophil chemotaxis [GO:0048245],
lymphocyte chemotaxis [GO:0048247],
chemokine-mediated signaling pathway [GO:0070098],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
negative regulation of leukocyte proliferation [GO:0070664],
cellular response to interferon-gamma [GO:0071346],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
immune response [GO:0006955],
positive regulation of myoblast differentiation [GO:0045663],
positive regulation of myoblast fusion [GO:1901741],

Molecular Function:
protein kinase activity [GO:0004672],
protein binding [GO:0005515],
chemokine activity [GO:0008009],
heparin binding [GO:0008201],
phospholipase activator activity [GO:0016004],
CCR chemokine receptor binding [GO:0048020],
cytokine activity [GO:0005125],

Cellular Component:
extracellular space [GO:0005615],
extracellular region [GO:0005576],