CCL5

C-C motif chemokine ligand 5

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24960204 Primary fibroblasts derived from ear Liver Mouse NO
26719346 B16-F10 Mouse NO
30987592 MCF7 Breast Human YES
31111482 Primary interstitial cells derived from ovary Ovary Mouse NO
31155496 Primary β cells derived from pancreas, MIN6 Mouse YES
31242426 HFF-2  Human YES
31424120 Primary cytotrophoblast cells derived from placenta Mouse NO
31431479 B16-F1 Human NO
31543366 Brain Mouse YES
31945125 Primary astrocytes derived from brain Human YES
32023351 Primary bone cells derived from bone marrow Mouse NO
32075966 IMR-90 Human YES
33470505 brain Mouse No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33552258 PANC-1 Human NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
dendritic cell chemotaxis [GO:0002407],
monocyte chemotaxis [GO:0002548],
regulation of chronic inflammatory response [GO:0002676],
calcium ion transport [GO:0006816],
cellular calcium ion homeostasis [GO:0006874],
exocytosis [GO:0006887],
chemotaxis [GO:0006935],
inflammatory response [GO:0006954],
leukocyte cell-cell adhesion [GO:0007159],
G-protein coupled receptor signaling pathway [GO:0007186],
cell-cell signaling [GO:0007267],
response to virus [GO:0009615],
response to toxic substance [GO:0009636],
positive regulation of activation of Janus kinase activity [GO:0010536],
positive regulation of macrophage chemotaxis [GO:0010759],
positive regulation of T cell chemotaxis [GO:0010820],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
positive regulation of smooth muscle cell migration [GO:0014911],
cytokine-mediated signaling pathway [GO:0019221],
positive regulation of cell migration [GO:0030335],
neutrophil chemotaxis [GO:0030593],
positive regulation of cellular biosynthetic process [GO:0031328],
activation of phospholipase D activity [GO:0031584],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
positive regulation of cell-cell adhesion mediated by integrin [GO:0033634],
positive regulation of homotypic cell-cell adhesion [GO:0034112],
positive regulation of T cell proliferation [GO:0042102],
neutrophil activation [GO:0042119],
positive regulation of phosphorylation [GO:0042327],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
protein kinase B signaling [GO:0043491],
positive regulation of GTPase activity [GO:0043547],
negative regulation by host of viral transcription [GO:0043922],
cellular response to fibroblast growth factor stimulus [GO:0044344],
positive regulation of viral genome replication [GO:0045070],
negative regulation of viral genome replication [GO:0045071],
positive regulation of innate immune response [GO:0045089],
negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744],
positive regulation of cell adhesion [GO:0045785],
positive regulation of translational initiation [GO:0045948],
positive regulation of JAK-STAT cascade [GO:0046427],
eosinophil chemotaxis [GO:0048245],
macrophage chemotaxis [GO:0048246],
lymphocyte chemotaxis [GO:0048247],
positive regulation of smooth muscle cell proliferation [GO:0048661],
positive regulation of epithelial cell proliferation [GO:0050679],
regulation of insulin secretion [GO:0050796],
regulation of T cell activation [GO:0050863],
positive chemotaxis [GO:0050918],
positive regulation of calcium ion transport [GO:0051928],
positive regulation of protein tyrosine kinase activity [GO:0061098],
chemokine-mediated signaling pathway [GO:0070098],
negative regulation of chemokine-mediated signaling pathway [GO:0070100],
negative regulation of T cell apoptotic process [GO:0070233],
positive regulation of T cell apoptotic process [GO:0070234],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to interferon-gamma [GO:0071346],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to organic cyclic compound [GO:0071407],
positive regulation of monocyte chemotaxis [GO:0090026],
regulation of neuron death [GO:1901214],
negative regulation of macrophage apoptotic process [GO:2000110],
positive regulation of T cell migration [GO:2000406],
positive regulation of natural killer cell chemotaxis [GO:2000503],
positive regulation of defense response to virus by host [GO:0002230],
immune response [GO:0006955],
positive regulation of gene expression [GO:0010628],
pseudopodium assembly [GO:0031269],
positive regulation of fever generation [GO:0031622],
response to cytokine [GO:0034097],
response to interferon-gamma [GO:0034341],
response to tumor necrosis factor [GO:0034612],
T-helper 1 cell diapedesis [GO:0035688],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of osteoclast differentiation [GO:0045672],
positive regulation of angiogenesis [GO:0045766],
negative regulation of cell death [GO:0060548],
positive regulation of mast cell chemotaxis [GO:0060754],
negative regulation of neuron death [GO:1901215],
positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343],

Molecular Function:
phosphatidylinositol phospholipase C activity [GO:0004435],
protein kinase activity [GO:0004672],
protein binding [GO:0005515],
chemokine activity [GO:0008009],
phospholipase activator activity [GO:0016004],
receptor signaling protein tyrosine kinase activator activity [GO:0030298],
CCR1 chemokine receptor binding [GO:0031726],
CCR4 chemokine receptor binding [GO:0031729],
CCR5 chemokine receptor binding [GO:0031730],
chemoattractant activity [GO:0042056],
chemokine receptor binding [GO:0042379],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
protein self-association [GO:0043621],
chemokine receptor antagonist activity [GO:0046817],
CCR chemokine receptor binding [GO:0048020],
cytokine activity [GO:0005125],
heparin binding [GO:0008201],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],