ACVR2A

activin A receptor type 2A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES

GO terms:

Biological Process:
gastrulation with mouth forming second [GO:0001702],
positive regulation of protein phosphorylation [GO:0001934],
protein phosphorylation [GO:0006468],
transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178],
spermatogenesis [GO:0007283],
determination of left/right symmetry [GO:0007368],
mesoderm development [GO:0007498],
anterior/posterior pattern specification [GO:0009952],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
positive regulation of bone mineralization [GO:0030501],
BMP signaling pathway [GO:0030509],
activin receptor signaling pathway [GO:0032924],
positive regulation of activin receptor signaling pathway [GO:0032927],
sperm ejaculation [GO:0042713],
penile erection [GO:0043084],
positive regulation of erythrocyte differentiation [GO:0045648],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
embryonic skeletal system development [GO:0048706],
regulation of nitric-oxide synthase activity [GO:0050999],
Sertoli cell proliferation [GO:0060011],
cellular response to growth factor stimulus [GO:0071363],
cellular response to BMP stimulus [GO:0071773],
male gonad development [GO:0008584],
regulation of signal transduction [GO:0009966],
phosphorylation [GO:0016310],
positive regulation of follicle-stimulating hormone secretion [GO:0046881],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
transmembrane receptor protein serine/threonine kinase activity [GO:0004675],
protein binding [GO:0005515],
ATP binding [GO:0005524],
coreceptor activity [GO:0015026],
activin-activated receptor activity [GO:0017002],
growth factor binding [GO:0019838],
PDZ domain binding [GO:0030165],
inhibin binding [GO:0034711],
protein self-association [GO:0043621],
metal ion binding [GO:0046872],
activin binding [GO:0048185],
BMP receptor activity [GO:0098821],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell surface [GO:0009986],
inhibin-betaglycan-ActRII complex [GO:0034673],
receptor complex [GO:0043235],
activin receptor complex [GO:0048179],
membrane [GO:0016020],
integral component of membrane [GO:0016021],