ACVR1C

activin A receptor type 1C

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

GO terms:

Biological Process:
trophectodermal cell proliferation [GO:0001834],
response to dietary excess [GO:0002021],
protein phosphorylation [GO:0006468],
nervous system development [GO:0007399],
response to glucose [GO:0009749],
lipid storage [GO:0019915],
cell differentiation [GO:0030154],
apoptotic nuclear changes [GO:0030262],
response to insulin [GO:0032868],
activin receptor signaling pathway [GO:0032924],
nodal signaling pathway [GO:0038092],
positive regulation of apoptotic process [GO:0043065],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
negative regulation of insulin secretion [GO:0046676],
cellular response to growth factor stimulus [GO:0071363],
negative regulation of trophoblast cell migration [GO:1901164],
negative regulation of chorionic trophoblast cell proliferation [GO:1901383],
in utero embryonic development [GO:0001701],
apoptotic process [GO:0006915],
transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178],
transforming growth factor beta receptor complex assembly [GO:0007181],
determination of left/right symmetry [GO:0007368],
phosphorylation [GO:0016310],
regulation of apoptotic process [GO:0042981],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
ATP binding [GO:0005524],
activin receptor activity, type I [GO:0016361],
growth factor binding [GO:0019838],
nodal binding [GO:0038100],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
transmembrane receptor protein serine/threonine kinase activity [GO:0004675],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
SMAD binding [GO:0046332],
activin binding [GO:0048185],
BMP receptor binding [GO:0070700],

Cellular Component:
plasma membrane [GO:0005886],
receptor complex [GO:0043235],
activin receptor complex [GO:0048179],
cytoplasm [GO:0005737],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],