activin A receptor type 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
angiogenesis [GO:0001525],
patterning of blood vessels [GO:0001569],
in utero embryonic development [GO:0001701],
gastrulation with mouth forming second [GO:0001702],
mesoderm formation [GO:0001707],
neural crest cell migration [GO:0001755],
acute inflammatory response [GO:0002526],
embryonic heart tube morphogenesis [GO:0003143],
outflow tract septum morphogenesis [GO:0003148],
atrioventricular valve morphogenesis [GO:0003181],
mitral valve morphogenesis [GO:0003183],
endocardial cushion morphogenesis [GO:0003203],
endocardial cushion fusion [GO:0003274],
atrial septum primum morphogenesis [GO:0003289],
protein phosphorylation [GO:0006468],
transforming growth factor beta receptor signaling pathway [GO:0007179],
germ cell development [GO:0007281],
determination of left/right symmetry [GO:0007368],
heart development [GO:0007507],
dorsal/ventral pattern formation [GO:0009953],
negative regulation of signal transduction [GO:0009968],
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862],
peptidyl-threonine phosphorylation [GO:0018107],
regulation of ossification [GO:0030278],
positive regulation of cell migration [GO:0030335],
positive regulation of bone mineralization [GO:0030501],
BMP signaling pathway [GO:0030509],
activin receptor signaling pathway [GO:0032924],
negative regulation of activin receptor signaling pathway [GO:0032926],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
smooth muscle cell differentiation [GO:0051145],
pharyngeal system development [GO:0060037],
pathway-restricted SMAD protein phosphorylation [GO:0060389],
ventricular septum morphogenesis [GO:0060412],
cardiac muscle cell fate commitment [GO:0060923],
BMP signaling pathway involved in heart development [GO:0061312],
endocardial cushion cell fate commitment [GO:0061445],
cellular response to growth factor stimulus [GO:0071363],
cellular response to BMP stimulus [GO:0071773],
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation [GO:1905007],
positive regulation of determination of dorsal identity [GO:2000017],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
urogenital system development [GO:0001655],
transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178],
gastrulation [GO:0007369],
mesoderm development [GO:0007498],
embryo development [GO:0009790],
phosphorylation [GO:0016310],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
transmembrane receptor protein serine/threonine kinase activity [GO:0004675],
transforming growth factor beta receptor activity, type I [GO:0005025],
protein binding [GO:0005515],
ATP binding [GO:0005524],
activin receptor activity, type I [GO:0016361],
peptide hormone binding [GO:0017046],
protein homodimerization activity [GO:0042803],
cadherin binding [GO:0045296],
SMAD binding [GO:0046332],
metal ion binding [GO:0046872],
activin binding [GO:0048185],
transforming growth factor beta binding [GO:0050431],
protein tyrosine kinase binding [GO:1990782],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
growth factor binding [GO:0019838],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
receptor complex [GO:0043235],
apical part of cell [GO:0045177],
activin receptor complex [GO:0048179],
BMP receptor complex [GO:0070724],
membrane [GO:0016020],
integral component of membrane [GO:0016021],