ACTN4

actinin alpha 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
platelet degranulation [GO:0002576],
protein transport [GO:0015031],
vesicle transport along actin filament [GO:0030050],
positive regulation of cell migration [GO:0030335],
positive regulation of sodium:proton antiporter activity [GO:0032417],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
peroxisome proliferator activated receptor signaling pathway [GO:0035357],
regulation of apoptotic process [GO:0042981],
retinoic acid receptor signaling pathway [GO:0048384],
positive regulation of pinocytosis [GO:0048549],
actin filament bundle assembly [GO:0051017],
negative regulation of cellular component movement [GO:0051271],
positive regulation of cellular component movement [GO:0051272],
bicellular tight junction assembly [GO:0070830],
negative regulation of substrate adhesion-dependent cell spreading [GO:1900025],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
protein localization to bicellular tight junction [GO:1902396],
regulation of nucleic acid-templated transcription [GO:1903506],
positive regulation of nucleic acid-templated transcription [GO:1903508],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
nucleoside binding [GO:0001882],
transcription coactivator activity [GO:0003713],
RNA binding [GO:0003723],
actin binding [GO:0003779],
integrin binding [GO:0005178],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374],
chromatin DNA binding [GO:0031490],
nuclear hormone receptor binding [GO:0035257],
protein homodimerization activity [GO:0042803],
retinoic acid receptor binding [GO:0042974],
ion channel binding [GO:0044325],
protein N-terminus binding [GO:0047485],
actin filament binding [GO:0051015],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],

Cellular Component:
stress fiber [GO:0001725],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
brush border [GO:0005903],
cell-cell junction [GO:0005911],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
nuclear body [GO:0016604],
Z disc [GO:0030018],
cortical cytoskeleton [GO:0030863],
platelet alpha granule lumen [GO:0031093],
pseudopodium [GO:0031143],
macromolecular complex [GO:0032991],
neuron projection [GO:0043005],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
ribonucleoprotein complex [GO:1990904],
cytoskeleton [GO:0005856],
cell junction [GO:0030054],