ACTN1

actinin alpha 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
platelet degranulation [GO:0002576],
actin filament organization [GO:0007015],
platelet activation [GO:0030168],
platelet formation [GO:0030220],
platelet morphogenesis [GO:0036344],
regulation of apoptotic process [GO:0042981],
focal adhesion assembly [GO:0048041],
actin filament bundle assembly [GO:0051017],
negative regulation of cellular component movement [GO:0051271],
actin filament network formation [GO:0051639],
actin crosslink formation [GO:0051764],
platelet aggregation [GO:0070527],
positive regulation of nucleic acid-templated transcription [GO:1903508],
cortical cytoskeleton organization [GO:0030865],
synapse organization [GO:0050808],

Molecular Function:
double-stranded RNA binding [GO:0003725],
integrin binding [GO:0005178],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
vinculin binding [GO:0017166],
ligand-dependent nuclear receptor transcription coactivator activity [GO:0030374],
protein homodimerization activity [GO:0042803],
ion channel binding [GO:0044325],
actin filament binding [GO:0051015],
actin binding [GO:0003779],
cytoskeletal regulatory protein binding [GO:0005519],
protein domain specific binding [GO:0019904],
metal ion binding [GO:0046872],

Cellular Component:
stress fiber [GO:0001725],
ruffle [GO:0001726],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
brush border [GO:0005903],
cell-cell junction [GO:0005911],
fascia adherens [GO:0005916],
focal adhesion [GO:0005925],
Z disc [GO:0030018],
platelet alpha granule lumen [GO:0031093],
pseudopodium [GO:0031143],
cell projection [GO:0042995],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
nucleus [GO:0005634],
cytoskeleton [GO:0005856],
membrane [GO:0016020],
sarcomere [GO:0030017],
cell junction [GO:0030054],
secretory granule [GO:0030141],
cortical cytoskeleton [GO:0030863],
cortical actin cytoskeleton [GO:0030864],
dense core granule membrane [GO:0032127],
dendritic spine [GO:0043197],