CBLB

Cbl proto-oncogene B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31534052 Kidney Mouse YES

GO terms:

Biological Process:
NLS-bearing protein import into nucleus [GO:0006607],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
negative regulation of epidermal growth factor-activated receptor activity [GO:0007175],
protein ubiquitination [GO:0016567],
regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000583],
positive regulation of T cell anergy [GO:0002669],
immune response [GO:0006955],
peptidyl-amino acid modification [GO:0018193],
regulation of signaling [GO:0023051],
regulation of cell adhesion [GO:0030155],
positive regulation of protein ubiquitination [GO:0031398],
intracellular signal transduction [GO:0035556],
T cell activation [GO:0042110],
regulation of GTPase activity [GO:0043087],
regulation of protein binding [GO:0043393],
positive regulation of protein catabolic process [GO:0045732],
negative regulation of alpha-beta T cell proliferation [GO:0046642],
T cell receptor signaling pathway [GO:0050852],
regulation of T cell receptor signaling pathway [GO:0050856],
negative regulation of T cell receptor signaling pathway [GO:0050860],

Molecular Function:
phosphotyrosine binding [GO:0001784],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
SH3 domain binding [GO:0017124],
receptor tyrosine kinase binding [GO:0030971],
ubiquitin protein ligase activity [GO:0061630],
ubiquitin-protein transferase activity [GO:0004842],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],
metal ion binding [GO:0046872],
aspartyltransferase activity [GO:0047690],

Cellular Component:
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
membrane raft [GO:0045121],
cytoplasm [GO:0005737],