CAV1

caveolin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
10781609 HDF, IMR-90 Skin Human NO
17662641 A549 Human NO
18439424 IMR-90  Human NO
18681962 Primary cells derived from nucleus pulposus Intervertebral disc Human NO
19820694 NIH 3T3 Lung Human, mouse NO
22829758 Lung Human NO
23637631 WI-38 Human NO
23941874 Primary fibroblasts derived from skin Rat NO
27048255 Glomerular mesangial cells derived from kidney Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29695496 RAW 264.7 Mouse NO
30987592 MCF7 Breast Human YES
31144244 Primary fibroblasts derived from skin Human NO
31155496 Primary β cells derived from pancreas Mouse YES
31811565 Primary neurons derived from brain Brain Human, mouse, rat YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
22362388 Lung Mouse NO
28514055 A549, HCT116, MEF Human, mouse NO
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
inactivation of MAPK activity [GO:0000188],
angiogenesis [GO:0001525],
vasculogenesis [GO:0001570],
response to hypoxia [GO:0001666],
negative regulation of endothelial cell proliferation [GO:0001937],
negative regulation of cytokine-mediated signaling pathway [GO:0001960],
response to ischemia [GO:0002931],
regulation of the force of heart contraction by chemical signal [GO:0003057],
triglyceride metabolic process [GO:0006641],
calcium ion transport [GO:0006816],
cellular calcium ion homeostasis [GO:0006874],
regulation of smooth muscle contraction [GO:0006940],
skeletal muscle tissue development [GO:0007519],
lactation [GO:0007595],
protein localization [GO:0008104],
response to bacterium [GO:0009617],
positive regulation of calcium ion transport into cytosol [GO:0010524],
posttranscriptional regulation of gene expression [GO:0010608],
positive regulation of gene expression [GO:0010628],
positive regulation of cholesterol efflux [GO:0010875],
positive regulation of peptidase activity [GO:0010952],
vesicle organization [GO:0016050],
receptor-mediated endocytosis of virus by host cell [GO:0019065],
regulation of fatty acid metabolic process [GO:0019217],
lipid storage [GO:0019915],
cell differentiation [GO:0030154],
regulation of blood coagulation [GO:0030193],
cholesterol transport [GO:0030301],
positive regulation of cell migration [GO:0030335],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
negative regulation of epithelial cell differentiation [GO:0030857],
mammary gland development [GO:0030879],
T cell costimulation [GO:0031295],
negative regulation of protein ubiquitination [GO:0031397],
positive regulation of protein ubiquitination [GO:0031398],
receptor internalization [GO:0031623],
negative regulation of protein binding [GO:0032091],
positive regulation of protein binding [GO:0032092],
maintenance of protein location in cell [GO:0032507],
response to progesterone [GO:0032570],
negative regulation of peptidyl-serine phosphorylation [GO:0033137],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
nitric oxide homeostasis [GO:0033484],
positive regulation of toll-like receptor 3 signaling pathway [GO:0034141],
insulin receptor internalization [GO:0038016],
vasoconstriction [GO:0042310],
negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532],
cholesterol homeostasis [GO:0042632],
positive regulation of catalytic activity [GO:0043085],
negative regulation of MAPK cascade [GO:0043409],
response to estrogen [GO:0043627],
protein localization to plasma membrane raft [GO:0044860],
negative regulation of nitric oxide biosynthetic process [GO:0045019],
positive regulation of vasoconstriction [GO:0045907],
negative regulation of JAK-STAT cascade [GO:0046426],
negative regulation of pinocytosis [GO:0048550],
leukocyte migration [GO:0050900],
regulation of nitric-oxide synthase activity [GO:0050999],
negative regulation of nitric-oxide synthase activity [GO:0051001],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
regulation of cytosolic calcium ion concentration [GO:0051480],
response to calcium ion [GO:0051592],
membrane depolarization [GO:0051899],
regulation of peptidase activity [GO:0052547],
calcium ion homeostasis [GO:0055074],
mammary gland involution [GO:0060056],
positive regulation of cell adhesion molecule production [GO:0060355],
negative regulation of necroptotic process [GO:0060546],
negative regulation of protein tyrosine kinase activity [GO:0061099],
caveola assembly [GO:0070836],
cellular response to exogenous dsRNA [GO:0071360],
cellular response to peptide hormone stimulus [GO:0071375],
cellular response to hyperoxia [GO:0071455],
cellular response to transforming growth factor beta stimulus [GO:0071560],
basement membrane organization [GO:0071711],
caveolin-mediated endocytosis [GO:0072584],
regulation of heart rate by cardiac conduction [GO:0086091],
angiotensin-activated signaling pathway involved in heart process [GO:0086098],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
apoptotic signaling pathway [GO:0097190],
regulation of membrane repolarization during action potential [GO:0098903],
regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909],
regulation of ventricular cardiac muscle cell action potential [GO:0098911],
regulation of ruffle assembly [GO:1900027],
negative regulation of peptidyl-tyrosine autophosphorylation [GO:1900085],
negative regulation of potassium ion transmembrane transport [GO:1901380],
regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844],
positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071],
protein localization to basolateral plasma membrane [GO:1903361],
positive regulation of gap junction assembly [GO:1903598],
negative regulation of inward rectifier potassium channel activity [GO:1903609],
beta-catenin destruction complex disassembly [GO:1904886],
receptor internalization involved in canonical Wnt signaling pathway [GO:2000286],
regulation of entry of bacterium into host cell [GO:2000535],
negative regulation of anoikis [GO:2000811],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
positive regulation of endothelial cell proliferation [GO:0001938],
regulation of the force of heart contraction [GO:0002026],
endocytosis [GO:0006897],
negative regulation of cell proliferation [GO:0008285],
response to mechanical stimulus [GO:0009612],
positive regulation of signal transduction [GO:0009967],
negative regulation of signal transduction [GO:0009968],
negative regulation of muscle cell apoptotic process [GO:0010656],
negative regulation of BMP signaling pathway [GO:0030514],
positive regulation of microtubule polymerization [GO:0031116],
cholesterol efflux [GO:0033344],
wound healing [GO:0042060],
negative regulation of MAP kinase activity [GO:0043407],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of endocytosis [GO:0045807],
microtubule polymerization [GO:0046785],
negative regulation of smooth muscle cell proliferation [GO:0048662],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
cellular response to mechanical stimulus [GO:0071260],
cellular senescence [GO:0090398],
negative regulation of cation channel activity [GO:2001258],

Molecular Function:
receptor binding [GO:0005102],
patched binding [GO:0005113],
protein binding [GO:0005515],
cholesterol binding [GO:0015485],
peptidase activator activity [GO:0016504],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
protein binding, bridging [GO:0030674],
identical protein binding [GO:0042802],
ion channel binding [GO:0044325],
macromolecular complex binding [GO:0044877],
protein heterodimerization activity [GO:0046982],
Rac GTPase binding [GO:0048365],
nitric-oxide synthase binding [GO:0050998],
ATPase binding [GO:0051117],
binding, bridging [GO:0060090],
inward rectifier potassium channel inhibitor activity [GO:0070320],
SNARE binding [GO:0000149],
kinase binding [GO:0019900],
syntaxin binding [GO:0019905],
receptor serine/threonine kinase binding [GO:0033612],

Cellular Component:
Golgi membrane [GO:0000139],
acrosomal membrane [GO:0002080],
caveolar macromolecular signaling complex [GO:0002095],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
lipid particle [GO:0005811],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
caveola [GO:0005901],
focal adhesion [GO:0005925],
cilium [GO:0005929],
cell cortex [GO:0005938],
membrane [GO:0016020],
endocytic vesicle membrane [GO:0030666],
cytoplasmic vesicle [GO:0031410],
early endosome membrane [GO:0031901],
macromolecular complex [GO:0032991],
sarcolemma [GO:0042383],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
peroxisomal membrane [GO:0005778],
cytosol [GO:0005829],
basal plasma membrane [GO:0009925],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],