CAV1
caveolin 1
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
Pubmed ID | Cell line | Tissue | Source | High-throughput |
10781609 | HDF, IMR-90 | Skin | Human | NO |
17662641 | A549 | Human | NO | |
18439424 | IMR-90Â | Human | NO | |
18681962 | Primary cells derived from nucleus pulposus | Intervertebral disc | Human | NO |
19820694 | NIH 3T3 | Lung | Human, mouse | NO |
22829758 | Lung | Human | NO | |
23637631 | WI-38 | Human | NO | |
23941874 | Primary fibroblasts derived from skin | Rat | NO | |
27048255 | Glomerular mesangial cells derived from kidney | Human | NO | |
29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
29695496 | RAW 264.7 | Mouse | NO | |
30987592 | MCF7 | Breast | Human | YES |
31144244 | Primary fibroblasts derived from skin | Human | NO | |
31155496 | Primary β cells derived from pancreas | Mouse | YES | |
31811565 | Primary neurons derived from brain | Brain | Human, mouse, rat | YES |
Status in senescence: Down-regulated | ||||
Pubmed ID | Cell line | Tissue | Source | High-throughput |
22362388 | Lung | Mouse | NO | |
28514055 | A549, HCT116, MEF | Human, mouse | NO | |
29548335 | Li Fraumeni | Human | YES |
GO terms:
Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
inactivation of MAPK activity [GO:0000188],
angiogenesis [GO:0001525],
vasculogenesis [GO:0001570],
response to hypoxia [GO:0001666],
negative regulation of endothelial cell proliferation [GO:0001937],
negative regulation of cytokine-mediated signaling pathway [GO:0001960],
response to ischemia [GO:0002931],
regulation of the force of heart contraction by chemical signal [GO:0003057],
triglyceride metabolic process [GO:0006641],
calcium ion transport [GO:0006816],
cellular calcium ion homeostasis [GO:0006874],
regulation of smooth muscle contraction [GO:0006940],
skeletal muscle tissue development [GO:0007519],
lactation [GO:0007595],
protein localization [GO:0008104],
response to bacterium [GO:0009617],
positive regulation of calcium ion transport into cytosol [GO:0010524],
posttranscriptional regulation of gene expression [GO:0010608],
positive regulation of gene expression [GO:0010628],
positive regulation of cholesterol efflux [GO:0010875],
positive regulation of peptidase activity [GO:0010952],
vesicle organization [GO:0016050],
receptor-mediated endocytosis of virus by host cell [GO:0019065],
regulation of fatty acid metabolic process [GO:0019217],
lipid storage [GO:0019915],
cell differentiation [GO:0030154],
regulation of blood coagulation [GO:0030193],
cholesterol transport [GO:0030301],
positive regulation of cell migration [GO:0030335],
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512],
negative regulation of epithelial cell differentiation [GO:0030857],
mammary gland development [GO:0030879],
T cell costimulation [GO:0031295],
negative regulation of protein ubiquitination [GO:0031397],
positive regulation of protein ubiquitination [GO:0031398],
receptor internalization [GO:0031623],
negative regulation of protein binding [GO:0032091],
positive regulation of protein binding [GO:0032092],
maintenance of protein location in cell [GO:0032507],
response to progesterone [GO:0032570],
negative regulation of peptidyl-serine phosphorylation [GO:0033137],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
nitric oxide homeostasis [GO:0033484],
positive regulation of toll-like receptor 3 signaling pathway [GO:0034141],
insulin receptor internalization [GO:0038016],
vasoconstriction [GO:0042310],
negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532],
cholesterol homeostasis [GO:0042632],
positive regulation of catalytic activity [GO:0043085],
negative regulation of MAPK cascade [GO:0043409],
response to estrogen [GO:0043627],
protein localization to plasma membrane raft [GO:0044860],
negative regulation of nitric oxide biosynthetic process [GO:0045019],
positive regulation of vasoconstriction [GO:0045907],
negative regulation of JAK-STAT cascade [GO:0046426],
negative regulation of pinocytosis [GO:0048550],
leukocyte migration [GO:0050900],
regulation of nitric-oxide synthase activity [GO:0050999],
negative regulation of nitric-oxide synthase activity [GO:0051001],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
regulation of cytosolic calcium ion concentration [GO:0051480],
response to calcium ion [GO:0051592],
membrane depolarization [GO:0051899],
regulation of peptidase activity [GO:0052547],
calcium ion homeostasis [GO:0055074],
mammary gland involution [GO:0060056],
positive regulation of cell adhesion molecule production [GO:0060355],
negative regulation of necroptotic process [GO:0060546],
negative regulation of protein tyrosine kinase activity [GO:0061099],
caveola assembly [GO:0070836],
cellular response to exogenous dsRNA [GO:0071360],
cellular response to peptide hormone stimulus [GO:0071375],
cellular response to hyperoxia [GO:0071455],
cellular response to transforming growth factor beta stimulus [GO:0071560],
basement membrane organization [GO:0071711],
caveolin-mediated endocytosis [GO:0072584],
regulation of heart rate by cardiac conduction [GO:0086091],
angiotensin-activated signaling pathway involved in heart process [GO:0086098],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
apoptotic signaling pathway [GO:0097190],
regulation of membrane repolarization during action potential [GO:0098903],
regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909],
regulation of ventricular cardiac muscle cell action potential [GO:0098911],
regulation of ruffle assembly [GO:1900027],
negative regulation of peptidyl-tyrosine autophosphorylation [GO:1900085],
negative regulation of potassium ion transmembrane transport [GO:1901380],
regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844],
positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071],
protein localization to basolateral plasma membrane [GO:1903361],
positive regulation of gap junction assembly [GO:1903598],
negative regulation of inward rectifier potassium channel activity [GO:1903609],
beta-catenin destruction complex disassembly [GO:1904886],
receptor internalization involved in canonical Wnt signaling pathway [GO:2000286],
regulation of entry of bacterium into host cell [GO:2000535],
negative regulation of anoikis [GO:2000811],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244],
positive regulation of endothelial cell proliferation [GO:0001938],
regulation of the force of heart contraction [GO:0002026],
endocytosis [GO:0006897],
negative regulation of cell proliferation [GO:0008285],
response to mechanical stimulus [GO:0009612],
positive regulation of signal transduction [GO:0009967],
negative regulation of signal transduction [GO:0009968],
negative regulation of muscle cell apoptotic process [GO:0010656],
negative regulation of BMP signaling pathway [GO:0030514],
positive regulation of microtubule polymerization [GO:0031116],
cholesterol efflux [GO:0033344],
wound healing [GO:0042060],
negative regulation of MAP kinase activity [GO:0043407],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of endocytosis [GO:0045807],
microtubule polymerization [GO:0046785],
negative regulation of smooth muscle cell proliferation [GO:0048662],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
cellular response to mechanical stimulus [GO:0071260],
cellular senescence [GO:0090398],
negative regulation of cation channel activity [GO:2001258],
Molecular Function:
receptor binding [GO:0005102],
patched binding [GO:0005113],
protein binding [GO:0005515],
cholesterol binding [GO:0015485],
peptidase activator activity [GO:0016504],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
protein binding, bridging [GO:0030674],
identical protein binding [GO:0042802],
ion channel binding [GO:0044325],
macromolecular complex binding [GO:0044877],
protein heterodimerization activity [GO:0046982],
Rac GTPase binding [GO:0048365],
nitric-oxide synthase binding [GO:0050998],
ATPase binding [GO:0051117],
binding, bridging [GO:0060090],
inward rectifier potassium channel inhibitor activity [GO:0070320],
SNARE binding [GO:0000149],
kinase binding [GO:0019900],
syntaxin binding [GO:0019905],
receptor serine/threonine kinase binding [GO:0033612],
Cellular Component:
Golgi membrane [GO:0000139],
acrosomal membrane [GO:0002080],
caveolar macromolecular signaling complex [GO:0002095],
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
lipid particle [GO:0005811],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
caveola [GO:0005901],
focal adhesion [GO:0005925],
cilium [GO:0005929],
cell cortex [GO:0005938],
membrane [GO:0016020],
endocytic vesicle membrane [GO:0030666],
cytoplasmic vesicle [GO:0031410],
early endosome membrane [GO:0031901],
macromolecular complex [GO:0032991],
sarcolemma [GO:0042383],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
peroxisomal membrane [GO:0005778],
cytosol [GO:0005829],
basal plasma membrane [GO:0009925],
cell surface [GO:0009986],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
apical plasma membrane [GO:0016324],