caspase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30693443 Cochlea Mouse NO
31882658 Primary mesenchymal stells derived from bone marrow Human NO
33403025 NCI-H520 Human No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
16904918 HDFa Human NO
31852919 Intervertebral disc Mouse NO
31940439 Human NO
33495462 SW 1353 Human No
32341413 Primary fibroblasts derived from skin Mouse No

GO terms:

Biological Process:
luteolysis [GO:0001554],
response to hypoxia [GO:0001666],
B cell homeostasis [GO:0001782],
apoptotic DNA fragmentation [GO:0006309],
proteolysis [GO:0006508],
apoptotic process [GO:0006915],
cellular response to DNA damage stimulus [GO:0006974],
axonal fasciculation [GO:0007413],
heart development [GO:0007507],
sensory perception of sound [GO:0007605],
learning or memory [GO:0007611],
intrinsic apoptotic signaling pathway in response to osmotic stress [GO:0008627],
response to UV [GO:0009411],
response to glucose [GO:0009749],
response to X-ray [GO:0010165],
regulation of macroautophagy [GO:0016241],
protein processing [GO:0016485],
cytokine-mediated signaling pathway [GO:0019221],
hippocampus development [GO:0021766],
neuron differentiation [GO:0030182],
keratinocyte differentiation [GO:0030216],
erythrocyte differentiation [GO:0030218],
platelet formation [GO:0030220],
negative regulation of B cell proliferation [GO:0030889],
regulation of protein stability [GO:0031647],
response to cobalt ion [GO:0032025],
response to estradiol [GO:0032355],
response to lipopolysaccharide [GO:0032496],
glial cell apoptotic process [GO:0034349],
response to tumor necrosis factor [GO:0034612],
response to nicotine [GO:0035094],
hippo signaling [GO:0035329],
wound healing [GO:0042060],
response to hydrogen peroxide [GO:0042542],
T cell homeostasis [GO:0043029],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
positive regulation of catalytic activity [GO:0043085],
response to amino acid [GO:0043200],
positive regulation of neuron apoptotic process [GO:0043525],
cell fate commitment [GO:0045165],
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736],
negative regulation of activated T cell proliferation [GO:0046007],
neurotrophin TRK receptor signaling pathway [GO:0048011],
striated muscle cell differentiation [GO:0051146],
response to glucocorticoid [GO:0051384],
neuron apoptotic process [GO:0051402],
anterior neural tube closure [GO:0061713],
leukocyte apoptotic process [GO:0071887],
cellular response to staurosporine [GO:0072734],
apoptotic signaling pathway [GO:0097190],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
execution phase of apoptosis [GO:0097194],
positive regulation of beta-amyloid formation [GO:1902004],
response to wounding [GO:0009611],
response to organic substance [GO:0010033],
intracellular signal transduction [GO:0035556],
negative regulation of cell cycle [GO:0045786],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
cellular response to organic substance [GO:0071310],

Molecular Function:
protease binding [GO:0002020],
aspartic-type endopeptidase activity [GO:0004190],
cysteine-type endopeptidase activity [GO:0004197],
cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861],
death receptor binding [GO:0005123],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
phospholipase A2 activator activity [GO:0016005],
macromolecular complex binding [GO:0044877],
cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153],
cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:0097199],
cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:0097200],
cysteine-type peptidase activity [GO:0008234],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
death-inducing signaling complex [GO:0031264],
neuronal cell body [GO:0043025],
membrane raft [GO:0045121],