ACTB

actin beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90, primary epithelial cells derived from kidney Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31562345 BJ Human NO

GO terms:

Biological Process:
regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079],
morphogenesis of a polarized epithelium [GO:0001738],
retina homeostasis [GO:0001895],
establishment or maintenance of cell polarity [GO:0007163],
axonogenesis [GO:0007409],
protein deubiquitination [GO:0016579],
substantia nigra development [GO:0021762],
regulation of transmembrane transporter activity [GO:0022898],
negative regulation of protein binding [GO:0032091],
cell junction assembly [GO:0034329],
adherens junction assembly [GO:0034333],
maintenance of blood-brain barrier [GO:0035633],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
ATP-dependent chromatin remodeling [GO:0043044],
apical protein localization [GO:0045176],
positive regulation of gene expression, epigenetic [GO:0045815],
ephrin receptor signaling pathway [GO:0048013],
synaptic vesicle endocytosis [GO:0048488],
cell motility [GO:0048870],
regulation of norepinephrine uptake [GO:0051621],
positive regulation of norepinephrine uptake [GO:0051623],
membrane organization [GO:0061024],
platelet aggregation [GO:0070527],
protein localization to adherens junction [GO:0071896],
cellular response to cytochalasin B [GO:0072749],
postsynaptic actin cytoskeleton organization [GO:0098974],
regulation of protein localization to plasma membrane [GO:1903076],
cellular response to electrical stimulus [GO:0071257],
negative regulation of cyclin-dependent protein kinase activity [GO:1904030],

Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
structural constituent of cytoskeleton [GO:0005200],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinesin binding [GO:0019894],
protein kinase binding [GO:0019901],
Tat protein binding [GO:0030957],
nucleosomal DNA binding [GO:0031492],
identical protein binding [GO:0042802],
tau protein binding [GO:0048156],
nitric-oxide synthase binding [GO:0050998],
structural constituent of postsynaptic actin cytoskeleton [GO:0098973],
nucleotide binding [GO:0000166],

Cellular Component:
nuclear chromatin [GO:0000790],
extracellular space [GO:0005615],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
adherens junction [GO:0005912],
focal adhesion [GO:0005925],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
lamellipodium [GO:0030027],
axon [GO:0030424],
cortical cytoskeleton [GO:0030863],
vesicle [GO:0031982],
macromolecular complex [GO:0032991],
NuA4 histone acetyltransferase complex [GO:0035267],
cytoplasmic ribonucleoprotein granule [GO:0036464],
apical junction complex [GO:0043296],
calyx of Held [GO:0044305],
synapse [GO:0045202],
extracellular exosome [GO:0070062],
occluding junction [GO:0070160],
blood microparticle [GO:0072562],
dense body [GO:0097433],
presynapse [GO:0098793],
postsynaptic actin cytoskeleton [GO:0098871],
glutamatergic synapse [GO:0098978],
ribonucleoprotein complex [GO:1990904],
stress fiber [GO:0001725],
podosome [GO:0002102],
postsynaptic density [GO:0014069],
myelin sheath [GO:0043209],
membrane raft [GO:0045121],