calpain 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
blastocyst development [GO:0001824],
proteolysis [GO:0006508],
myoblast fusion [GO:0007520],
female pregnancy [GO:0007565],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
extracellular matrix disassembly [GO:0022617],
regulation of interleukin-6 production [GO:0032675],
cellular response to interferon-beta [GO:0035458],
response to hydrogen peroxide [GO:0042542],
behavioral response to pain [GO:0048266],
regulation of cytoskeleton organization [GO:0051493],
proteolysis involved in cellular protein catabolic process [GO:0051603],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to amino acid stimulus [GO:0071230],
positive regulation of neuron death [GO:1901216],
positive regulation of myoblast fusion [GO:1901741],
positive regulation of phosphatidylcholine biosynthetic process [GO:2001247],
protein autoprocessing [GO:0016540],

Molecular Function:
calcium-dependent cysteine-type endopeptidase activity [GO:0004198],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
cytoskeletal protein binding [GO:0008092],
cysteine-type peptidase activity [GO:0008234],
enzyme binding [GO:0019899],
macromolecular complex binding [GO:0044877],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
chromatin [GO:0000785],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrial intermembrane space [GO:0005758],
lysosome [GO:0005764],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
external side of plasma membrane [GO:0009897],
dendrite [GO:0030425],
cortical actin cytoskeleton [GO:0030864],
pseudopodium [GO:0031143],
neuronal cell body [GO:0043025],
membrane raft [GO:0045121],
extracellular exosome [GO:0070062],
perinuclear endoplasmic reticulum [GO:0097038],
intracellular [GO:0005622],
membrane [GO:0016020],
cell projection [GO:0042995],