CAMK2D

calcium/calmodulin dependent protein kinase II delta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
regulation of cell growth [GO:0001558],
regulation of the force of heart contraction [GO:0002026],
regulation of membrane depolarization [GO:0003254],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
protein phosphorylation [GO:0006468],
regulation of heart contraction [GO:0008016],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
regulation of cell communication by electrical coupling [GO:0010649],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880],
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
endoplasmic reticulum calcium ion homeostasis [GO:0032469],
protein autophosphorylation [GO:0046777],
relaxation of cardiac muscle [GO:0055119],
regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314],
interferon-gamma-mediated signaling pathway [GO:0060333],
regulation of cellular localization [GO:0060341],
cellular response to calcium ion [GO:0071277],
cardiac muscle cell contraction [GO:0086003],
regulation of heart rate by cardiac conduction [GO:0086091],
regulation of cardiac muscle cell action potential [GO:0098901],
regulation of cardiac muscle cell action potential involved in regulation of contraction [GO:0098909],
regulation of cellular response to heat [GO:1900034],
regulation of histone deacetylase activity [GO:1901725],
regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844],
regulation of relaxation of cardiac muscle [GO:1901897],
negative regulation of sodium ion transmembrane transport [GO:1902306],
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel [GO:1902514],
negative regulation of sodium ion transmembrane transporter activity [GO:2000650],
G1/S transition of mitotic cell cycle [GO:0000082],
response to hypoxia [GO:0001666],
regulation of sodium ion transport [GO:0002028],
calcium ion transport [GO:0006816],
positive regulation of G2/M transition of mitotic cell cycle [GO:0010971],
positive regulation of smooth muscle cell migration [GO:0014911],
phosphorylation [GO:0016310],
cellular potassium ion homeostasis [GO:0030007],
positive regulation of Rac protein signal transduction [GO:0035022],
cardiac muscle contraction [GO:0060048],
cell growth involved in cardiac muscle cell development [GO:0061049],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
regulation of protein localization to plasma membrane [GO:1903076],
positive regulation of vascular smooth muscle cell proliferation [GO:1904707],
positive regulation of DNA biosynthetic process [GO:2000573],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
calmodulin-dependent protein kinase activity [GO:0004683],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
sodium channel inhibitor activity [GO:0019871],
titin binding [GO:0031432],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
ion channel binding [GO:0044325],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
nitric-oxide synthase binding [GO:0050998],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
calcium- and calmodulin-dependent protein kinase complex [GO:0005954],
membrane [GO:0016020],
endocytic vesicle membrane [GO:0030666],
sarcoplasmic reticulum membrane [GO:0033017],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
plasma membrane [GO:0005886],
intercalated disc [GO:0014704],
sarcoplasmic reticulum [GO:0016529],
T-tubule [GO:0030315],
neuromuscular junction [GO:0031594],
macromolecular complex [GO:0032991],
neuronal cell body [GO:0043025],
axon initial segment [GO:0043194],
perinuclear region of cytoplasm [GO:0048471],