calcium/calmodulin dependent protein kinase II alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
response to ischemia [GO:0002931],
protein phosphorylation [GO:0006468],
calcium ion transport [GO:0006816],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
peptidyl-serine phosphorylation [GO:0018105],
angiotensin-activated signaling pathway [GO:0038166],
protein autophosphorylation [GO:0046777],
regulation of neurotransmitter secretion [GO:0046928],
regulation of neuronal synaptic plasticity [GO:0048168],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
negative regulation of hydrolase activity [GO:0051346],
positive regulation of calcium ion transport [GO:0051928],
interferon-gamma-mediated signaling pathway [GO:0060333],
dendritic spine development [GO:0060996],
regulation of cellular response to heat [GO:1900034],
regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902108],
peptidyl-threonine autophosphorylation [GO:1990443],
regulation of endocannabinoid signaling pathway [GO:2000124],
regulation of neuron migration [GO:2001222],
phosphorylation [GO:0016310],
ionotropic glutamate receptor signaling pathway [GO:0035235],
dendrite morphogenesis [GO:0048813],
postsynaptic neurotransmitter receptor diffusion trapping [GO:0098970],
NMDA selective glutamate receptor signaling pathway [GO:0098989],
calmodulin dependent kinase signaling pathway [GO:0099004],
regulation of protein localization to plasma membrane [GO:1903076],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
calmodulin-dependent protein kinase activity [GO:0004683],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
ATP binding [GO:0005524],
calcium-dependent protein serine/threonine kinase activity [GO:0009931],
kinase activity [GO:0016301],
glutamate receptor binding [GO:0035254],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
transferase activity [GO:0016740],
GTPase activating protein binding [GO:0032794],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
calcium- and calmodulin-dependent protein kinase complex [GO:0005954],
postsynaptic density [GO:0014069],
endocytic vesicle membrane [GO:0030666],
neuron projection [GO:0043005],
dendritic spine [GO:0043197],
membrane [GO:0016020],
cell junction [GO:0030054],
axon [GO:0030424],
dendrite [GO:0030425],
dendrite cytoplasm [GO:0032839],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
synapse [GO:0045202],
glutamatergic synapse [GO:0098978],
presynaptic cytosol [GO:0099523],
postsynaptic cytosol [GO:0099524],
glutamatergic postsynaptic density [GO:0099573],