actin alpha 2, smooth muscle

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30265659 Kidney Mouse NO
31464599 Primary fibroblasts derived from lung Human NO
31931659 WI-38 Human NO
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Li Fraumeni Human YES
32523550 HCASMC Human No
32973510 Kidney Mouse NO

GO terms:

Biological Process:
muscle contraction [GO:0006936],
regulation of blood pressure [GO:0008217],
response to virus [GO:0009615],
positive regulation of gene expression [GO:0010628],
vascular smooth muscle contraction [GO:0014829],
positive regulation of transcription, DNA-templated [GO:0045893],
glomerular mesangial cell development [GO:0072144],
mesenchyme migration [GO:0090131],
regulation of wound healing [GO:0061041],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of hepatic stellate cell activation [GO:2000491],

Molecular Function:
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
nucleotide binding [GO:0000166],
protein binding [GO:0005515],

Cellular Component:
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
dynactin complex [GO:0005869],
actin cytoskeleton [GO:0015629],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
smooth muscle contractile fiber [GO:0030485],
macromolecular complex [GO:0032991],
cell body [GO:0044297],
extracellular exosome [GO:0070062],
stress fiber [GO:0001725],
cytoskeleton [GO:0005856],