ACTA2
actin alpha 2, smooth muscle
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 30265659 | Kidney | Mouse | NO | |
| 31464599 | Primary fibroblasts derived from lung | Human | NO | |
| 31931659 | WI-38 | Human | NO | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
| 31983656 | MSC | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 27323328 | Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni | Human | YES | |
| 29548335 | Li Fraumeni | Human | YES | |
| 32523550 | HCASMC | Human | No | |
| 32973510 | Kidney | Mouse | NO | |
GO terms:
Biological Process:
muscle contraction [GO:0006936],
regulation of blood pressure [GO:0008217],
response to virus [GO:0009615],
positive regulation of gene expression [GO:0010628],
vascular smooth muscle contraction [GO:0014829],
positive regulation of transcription, DNA-templated [GO:0045893],
glomerular mesangial cell development [GO:0072144],
mesenchyme migration [GO:0090131],
regulation of wound healing [GO:0061041],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
positive regulation of hepatic stellate cell activation [GO:2000491],
Molecular Function:
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
Cellular Component:
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
dynactin complex [GO:0005869],
actin cytoskeleton [GO:0015629],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
smooth muscle contractile fiber [GO:0030485],
macromolecular complex [GO:0032991],
cell body [GO:0044297],
extracellular exosome [GO:0070062],
stress fiber [GO:0001725],
cytoskeleton [GO:0005856],