ACTA1

actin alpha 1, skeletal muscle

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES
31962055 IMR-90, primary fibroblasts derived from lung Lung Human, mouse NO

GO terms:

Biological Process:
muscle contraction [GO:0006936],
response to mechanical stimulus [GO:0009612],
response to extracellular stimulus [GO:0009991],
response to lithium ion [GO:0010226],
positive regulation of gene expression [GO:0010628],
muscle filament sliding [GO:0030049],
skeletal muscle thin filament assembly [GO:0030240],
skeletal muscle fiber adaptation [GO:0043503],
response to steroid hormone [GO:0048545],
skeletal muscle fiber development [GO:0048741],
cellular response to organonitrogen compound [GO:0071417],
mesenchyme migration [GO:0090131],

Molecular Function:
structural constituent of cytoskeleton [GO:0005200],
protein binding [GO:0005515],
ATP binding [GO:0005524],
myosin binding [GO:0017022],
ADP binding [GO:0043531],
nucleotide binding [GO:0000166],

Cellular Component:
stress fiber [GO:0001725],
extracellular space [GO:0005615],
cytosol [GO:0005829],
striated muscle thin filament [GO:0005865],
dynactin complex [GO:0005869],
actin filament [GO:0005884],
actin cytoskeleton [GO:0015629],
sarcomere [GO:0030017],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
cell body [GO:0044297],
extracellular exosome [GO:0070062],
blood microparticle [GO:0072562],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
macromolecular complex [GO:0032991],