alanyl-tRNA synthetase 2, mitochondrial

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Saos-2 Human YES

GO terms:

Biological Process:
tRNA modification [GO:0006400],
alanyl-tRNA aminoacylation [GO:0006419],
mitochondrial alanyl-tRNA aminoacylation [GO:0070143],
translation [GO:0006412],
tRNA aminoacylation [GO:0043039],

Molecular Function:
tRNA binding [GO:0000049],
aminoacyl-tRNA editing activity [GO:0002161],
alanine-tRNA ligase activity [GO:0004813],
ATP binding [GO:0005524],
zinc ion binding [GO:0008270],
amino acid binding [GO:0016597],
nucleotide binding [GO:0000166],
nucleic acid binding [GO:0003676],
RNA binding [GO:0003723],
aminoacyl-tRNA ligase activity [GO:0004812],
ligase activity [GO:0016874],
metal ion binding [GO:0046872],

Cellular Component:
mitochondrion [GO:0005739],
cytoplasm [GO:0005737],