C9orf72-SMCR8 complex subunit

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
negative regulation of protein phosphorylation [GO:0001933],
endocytosis [GO:0006897],
autophagy [GO:0006914],
regulation of autophagy [GO:0010506],
positive regulation of macroautophagy [GO:0016239],
stress granule assembly [GO:0034063],
axon extension [GO:0048675],
late endosome to lysosome transport [GO:1902774],
regulation of TORC1 signaling [GO:1903432],
negative regulation of GTP binding [GO:1904425],
regulation of autophagosome assembly [GO:2000785],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
protein binding [GO:0005515],
Rab guanyl-nucleotide exchange factor activity [GO:0017112],
Rab GTPase binding [GO:0017137],

Cellular Component:
cytoplasmic mRNA processing body [GO:0000932],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
endosome [GO:0005768],
autophagosome [GO:0005776],
cytoplasmic stress granule [GO:0010494],
dendrite [GO:0030425],
cytoplasmic vesicle [GO:0031410],
nuclear membrane [GO:0031965],
guanyl-nucleotide exchange factor complex [GO:0032045],
cell projection [GO:0042995],
neuron projection [GO:0043005],
perikaryon [GO:0043204],
axonal growth cone [GO:0044295],
main axon [GO:0044304],
ATG1/ULK1 kinase complex [GO:1990316],