ACSL4

acyl-CoA synthetase long chain family member 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
long-chain fatty acid metabolic process [GO:0001676],
lipid metabolic process [GO:0006629],
response to nutrient [GO:0007584],
fatty acid transport [GO:0015908],
triglyceride biosynthetic process [GO:0019432],
neuron differentiation [GO:0030182],
positive regulation of insulin secretion [GO:0032024],
long-chain fatty-acyl-CoA metabolic process [GO:0035336],
long-chain fatty-acyl-CoA biosynthetic process [GO:0035338],
embryonic process involved in female pregnancy [GO:0060136],
dendritic spine development [GO:0060996],
response to interleukin-15 [GO:0070672],
fatty acid metabolic process [GO:0006631],
lipid biosynthetic process [GO:0008610],
regulation of fatty acid metabolic process [GO:0019217],
positive regulation of cell growth [GO:0030307],
negative regulation of prostaglandin secretion [GO:0032307],

Molecular Function:
acyl-CoA ligase activity [GO:0003996],
long-chain fatty acid-CoA ligase activity [GO:0004467],
ATP binding [GO:0005524],
very long-chain fatty acid-CoA ligase activity [GO:0031957],
arachidonate-CoA ligase activity [GO:0047676],
decanoate--CoA ligase activity [GO:0102391],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
ligase activity [GO:0016874],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrial outer membrane [GO:0005741],
peroxisomal membrane [GO:0005778],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
lipid particle [GO:0005811],
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
neuronal cell body [GO:0043025],
ER-mitochondrion membrane contact site [GO:0044233],
extracellular exosome [GO:0070062],
mitochondrion [GO:0005739],
peroxisome [GO:0005777],
mitochondrial membrane [GO:0031966],
intracellular membrane-bounded organelle [GO:0043231],