ACSL3

acyl-CoA synthetase long chain family member 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES
31983656 IPSC-MSC Human YES

GO terms:

Biological Process:
long-chain fatty acid metabolic process [GO:0001676],
fatty acid biosynthetic process [GO:0006633],
brain development [GO:0007420],
response to nutrient [GO:0007584],
response to organic cyclic compound [GO:0014070],
neuron differentiation [GO:0030182],
very-low-density lipoprotein particle assembly [GO:0034379],
long-chain fatty-acyl-CoA metabolic process [GO:0035336],
long-chain fatty-acyl-CoA biosynthetic process [GO:0035338],
positive regulation of Golgi to plasma membrane protein transport [GO:0042998],
long-chain fatty acid import [GO:0044539],
positive regulation of secretion [GO:0051047],
positive regulation of phosphatidylcholine biosynthetic process [GO:2001247],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],

Molecular Function:
acyl-CoA ligase activity [GO:0003996],
long-chain fatty acid-CoA ligase activity [GO:0004467],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
arachidonate-CoA ligase activity [GO:0047676],
decanoate--CoA ligase activity [GO:0102391],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
ligase activity [GO:0016874],

Cellular Component:
mitochondrial outer membrane [GO:0005741],
peroxisomal membrane [GO:0005778],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
Golgi apparatus [GO:0005794],
lipid particle [GO:0005811],
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
perinuclear region of cytoplasm [GO:0048471],
mitochondrion [GO:0005739],
peroxisome [GO:0005777],
intracellular membrane-bounded organelle [GO:0043231],