ACSL1

acyl-CoA synthetase long chain family member 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31442231 Muscle Mouse NO

GO terms:

Biological Process:
very long-chain fatty acid metabolic process [GO:0000038],
long-chain fatty acid metabolic process [GO:0001676],
response to nutrient [GO:0007584],
lipid biosynthetic process [GO:0008610],
response to organic cyclic compound [GO:0014070],
regulation of lipid metabolic process [GO:0019216],
triglyceride biosynthetic process [GO:0019432],
adiponectin-activated signaling pathway [GO:0033211],
response to oleic acid [GO:0034201],
long-chain fatty-acyl-CoA biosynthetic process [GO:0035338],
alpha-linolenic acid metabolic process [GO:0036109],
xenobiotic catabolic process [GO:0042178],
response to drug [GO:0042493],
linoleic acid metabolic process [GO:0043651],
long-chain fatty acid import [GO:0044539],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
lipid metabolic process [GO:0006629],
fatty acid metabolic process [GO:0006631],
response to organic substance [GO:0010033],
fatty acid transport [GO:0015908],

Molecular Function:
acyl-CoA ligase activity [GO:0003996],
long-chain fatty acid-CoA ligase activity [GO:0004467],
ATP binding [GO:0005524],
arachidonate-CoA ligase activity [GO:0047676],
phytanate-CoA ligase activity [GO:0050197],
decanoate--CoA ligase activity [GO:0102391],
nucleotide binding [GO:0000166],
catalytic activity [GO:0003824],
ligase activity [GO:0016874],
acetate-CoA ligase (ADP-forming) activity [GO:0043758],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
peroxisomal membrane [GO:0005778],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
peroxisome [GO:0005777],
intracellular membrane-bounded organelle [GO:0043231],