ZMPSTE24

zinc metallopeptidase STE24

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
16079796 Primary fibroblasts Mouse NO
24101728 MSC Human NO

GO terms:

Biological Process:
liver development [GO:0001889],
hair follicle development [GO:0001942],
heart morphogenesis [GO:0003007],
ventricular cardiac muscle tissue development [GO:0003229],
cardiac ventricle development [GO:0003231],
growth plate cartilage development [GO:0003417],
DNA repair [GO:0006281],
proteolysis [GO:0006508],
inflammatory cell apoptotic process [GO:0006925],
nuclear envelope organization [GO:0006998],
adult walking behavior [GO:0007628],
determination of adult lifespan [GO:0008340],
regulation of cell shape [GO:0008360],
regulation of autophagy [GO:0010506],
regulation of glucose metabolic process [GO:0010906],
regulation of lipid metabolic process [GO:0019216],
bone mineralization [GO:0030282],
prenylated protein catabolic process [GO:0030327],
regulation of bone mineralization [GO:0030500],
regulation of TOR signaling [GO:0032006],
regulation of hormone metabolic process [GO:0032350],
multicellular organism growth [GO:0035264],
regulation of multicellular organism growth [GO:0040014],
maintenance of rDNA [GO:0043007],
regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043516],
histone H2B-K5 acetylation [GO:0043979],
hypomethylation of CpG island [GO:0044029],
cellular lipid metabolic process [GO:0044255],
regulation of fibroblast proliferation [GO:0048145],
thymus development [GO:0048538],
cardiac muscle fiber development [GO:0048739],
regulation of defense response to virus [GO:0050688],
neuromuscular process [GO:0050905],
regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307],
kidney morphogenesis [GO:0060993],
cardiac conduction [GO:0061337],
CAMKK-AMPK signaling cascade [GO:0061762],
regulation of stress-activated protein kinase signaling cascade [GO:0070302],
cellular response to gamma radiation [GO:0071480],
CAAX-box protein processing [GO:0071586],
response to DNA damage checkpoint signaling [GO:0072423],
regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025],
regulation of mitotic cell cycle DNA replication [GO:1903463],
negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799],
calcium ion import into sarcoplasmic reticulum [GO:1990036],
histone H2A phosphorylation [GO:1990164],
regulation of histone H4-K16 acetylation [GO:2000618],
regulation of termination of RNA polymerase I transcription [GO:2000730],
regulation of cellular senescence [GO:2000772],
chromatin organization [GO:0006325],
regulation of transcription, DNA-templated [GO:0006355],
cellular response to DNA damage stimulus [GO:0006974],
nucleus organization [GO:0006997],
regulation of mitotic cell cycle [GO:0007346],
regulation of heart contraction [GO:0008016],
epidermis development [GO:0008544],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
protein processing [GO:0016485],
histone H2B acetylation [GO:0043969],
regulation of DNA methylation [GO:0044030],
chromosome organization [GO:0051276],
regulation of histone H4 acetylation [GO:0090239],
regulation of blood circulation [GO:1903522],

Molecular Function:
double-stranded DNA binding [GO:0003690],
metalloendopeptidase activity [GO:0004222],
protein binding [GO:0005515],
metalloexopeptidase activity [GO:0008235],
metal ion binding [GO:0046872],
endopeptidase activity [GO:0004175],
peptidase activity [GO:0008233],
metallopeptidase activity [GO:0008237],
hydrolase activity [GO:0016787],

Cellular Component:
nuclear inner membrane [GO:0005637],
membrane [GO:0016020],
integral component of endoplasmic reticulum membrane [GO:0030176],
macromolecular complex [GO:0032991],
extracellular exosome [GO:0070062],
nucleus [GO:0005634],
nuclear envelope [GO:0005635],
endoplasmic reticulum [GO:0005783],
integral component of membrane [GO:0016021],