ZIC3

Zic family member 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
heart looping [GO:0001947],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
determination of left/right symmetry [GO:0007368],
central nervous system development [GO:0007417],
anterior/posterior pattern specification [GO:0009952],
cell differentiation [GO:0030154],
lung development [GO:0030324],
somatic stem cell population maintenance [GO:0035019],
determination of pancreatic left/right asymmetry [GO:0035469],
determination of left/right asymmetry in nervous system [GO:0035545],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
determination of digestive tract left/right asymmetry [GO:0071907],
determination of liver left/right asymmetry [GO:0071910],
multicellular organism development [GO:0007275],
pattern specification process [GO:0007389],
nervous system development [GO:0007399],

Molecular Function:
RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001228],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
sequence-specific DNA binding [GO:0043565],
metal ion binding [GO:0046872],
nucleic acid binding [GO:0003676],
DNA binding [GO:0003677],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],