ZFP36

ZFP36 ring finger protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20157568 HeLa Cervix Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
MAPK cascade [GO:0000165],
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288],
nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289],
mRNA catabolic process [GO:0006402],
response to wounding [GO:0009611],
regulation of keratinocyte proliferation [GO:0010837],
viral process [GO:0016032],
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086],
regulation of tumor necrosis factor production [GO:0032680],
negative regulation of viral transcription [GO:0032897],
miRNA mediated inhibition of translation [GO:0035278],
p38MAPK cascade [GO:0038066],
response to starvation [GO:0042594],
regulation of mRNA stability [GO:0043488],
cellular response to fibroblast growth factor stimulus [GO:0044344],
negative regulation of interleukin-2 biosynthetic process [GO:0045085],
positive regulation of fat cell differentiation [GO:0045600],
regulation of keratinocyte differentiation [GO:0045616],
negative regulation of erythrocyte differentiation [GO:0045647],
mRNA transport [GO:0051028],
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213],
3'-UTR-mediated mRNA destabilization [GO:0061158],
3'-UTR-mediated mRNA stabilization [GO:0070935],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to tumor necrosis factor [GO:0071356],
cellular response to epidermal growth factor stimulus [GO:0071364],
cellular response to glucocorticoid stimulus [GO:0071385],
cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011],
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153],
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA [GO:1901835],
regulation of keratinocyte apoptotic process [GO:1902172],
negative regulation of polynucleotide adenylyltransferase activity [GO:1904246],
positive regulation of intracellular mRNA localization [GO:1904582],
positive regulation of gene silencing by miRNA [GO:2000637],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
multicellular organism development [GO:0007275],
intracellular signal transduction [GO:0035556],
negative regulation of myeloid cell differentiation [GO:0045638],
negative regulation of inflammatory response [GO:0050728],
RNA destabilization [GO:0050779],
positive regulation of mRNA catabolic process [GO:0061014],

Molecular Function:
DNA binding [GO:0003677],
RNA binding [GO:0003723],
mRNA binding [GO:0003729],
protein binding [GO:0005515],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
C-C chemokine binding [GO:0019957],
heat shock protein binding [GO:0031072],
mRNA 3'-UTR AU-rich region binding [GO:0035925],
metal ion binding [GO:0046872],
RNA polymerase binding [GO:0070063],
14-3-3 protein binding [GO:0071889],
mRNA 3'-UTR binding [GO:0003730],

Cellular Component:
exosome (RNase complex) [GO:0000178],
cytoplasmic mRNA processing body [GO:0000932],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoplasmic stress granule [GO:0010494],
CCR4-NOT complex [GO:0030014],
RISC-loading complex [GO:0070578],
Dcp1-Dcp2 complex [GO:0098745],
ribonucleoprotein complex [GO:1990904],