ZC3H12A

zinc finger CCCH-type containing 12A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [GO:0000294],
angiogenesis [GO:0001525],
negative regulation of protein phosphorylation [GO:0001933],
positive regulation of defense response to virus by host [GO:0002230],
immune response-activating signal transduction [GO:0002757],
apoptotic process [GO:0006915],
inflammatory response [GO:0006954],
cellular response to DNA damage stimulus [GO:0006974],
nervous system development [GO:0007399],
regulation of gene expression [GO:0010468],
positive regulation of autophagy [GO:0010508],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
negative regulation of muscle cell apoptotic process [GO:0010656],
positive regulation of lipid storage [GO:0010884],
positive regulation of cell death [GO:0010942],
viral process [GO:0016032],
protein deubiquitination [GO:0016579],
cell differentiation [GO:0030154],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
negative regulation of interleukin-6 production [GO:0032715],
negative regulation of tumor necrosis factor production [GO:0032720],
cellular response to oxidative stress [GO:0034599],
cellular response to glucose starvation [GO:0042149],
positive regulation of protein import into nucleus [GO:0042307],
negative regulation of macrophage activation [GO:0043031],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
negative regulation by host of viral genome replication [GO:0044828],
negative regulation of nitric oxide biosynthetic process [GO:0045019],
positive regulation of fat cell differentiation [GO:0045600],
positive regulation of angiogenesis [GO:0045766],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of interleukin-1 beta secretion [GO:0050713],
T cell receptor signaling pathway [GO:0050852],
protein oligomerization [GO:0051259],
defense response to virus [GO:0051607],
negative regulation of cardiac muscle contraction [GO:0055118],
positive regulation of mRNA catabolic process [GO:0061014],
3'-UTR-mediated mRNA destabilization [GO:0061158],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
RNA phosphodiester bond hydrolysis [GO:0090501],
RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502],
RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503],
cellular response to virus [GO:0098586],
negative regulation of cytokine production involved in inflammatory response [GO:1900016],
positive regulation of execution phase of apoptosis [GO:1900119],
negative regulation of interleukin-6 secretion [GO:1900165],
positive regulation of p38MAPK cascade [GO:1900745],
negative regulation of NIK/NF-kappaB signaling [GO:1901223],
negative regulation of interferon-gamma secretion [GO:1902714],
positive regulation of protein deubiquitination [GO:1903003],
negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799],
cellular response to sodium arsenite [GO:1903936],
negative regulation of tumor necrosis factor secretion [GO:1904468],
cellular response to ionomycin [GO:1904637],
cellular response to chemokine [GO:1990869],
negative regulation of T-helper 17 cell differentiation [GO:2000320],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
positive regulation of miRNA catabolic process [GO:2000627],
immune system process [GO:0002376],
multicellular organism development [GO:0007275],

Molecular Function:
DNA binding [GO:0003677],
chromatin binding [GO:0003682],
RNA binding [GO:0003723],
mRNA binding [GO:0003729],
mRNA 3'-UTR binding [GO:0003730],
endoribonuclease activity [GO:0004521],
exoribonuclease activity [GO:0004532],
ribonuclease activity [GO:0004540],
thiol-dependent ubiquitin-specific protease activity [GO:0004843],
protein binding [GO:0005515],
miRNA binding [GO:0035198],
RNA stem-loop binding [GO:0035613],
mRNA 3'-UTR AU-rich region binding [GO:0035925],
ribosome binding [GO:0043022],
metal ion binding [GO:0046872],
nuclease activity [GO:0004518],
endonuclease activity [GO:0004519],
hydrolase activity [GO:0016787],

Cellular Component:
cytoplasmic mRNA processing body [GO:0000932],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
rough endoplasmic reticulum [GO:0005791],
cytoskeleton [GO:0005856],
rough endoplasmic reticulum membrane [GO:0030867],
macromolecular complex [GO:0032991],
cytoplasmic ribonucleoprotein granule [GO:0036464],
extrinsic component of endoplasmic reticulum membrane [GO:0042406],
endoplasmic reticulum [GO:0005783],
membrane [GO:0016020],