YWHAE

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
G2/M transition of mitotic cell cycle [GO:0000086],
MAPK cascade [GO:0000165],
neuron migration [GO:0001764],
regulation of heart rate by hormone [GO:0003064],
protein targeting [GO:0006605],
regulation of G2/M transition of mitotic cell cycle [GO:0010389],
viral process [GO:0016032],
substantia nigra development [GO:0021762],
hippocampus development [GO:0021766],
cerebral cortex development [GO:0021987],
protein localization to nucleus [GO:0034504],
cellular response to heat [GO:0034605],
hippo signaling [GO:0035329],
intracellular signal transduction [GO:0035556],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
positive regulation of protein export from nucleus [GO:0046827],
regulation of cytosolic calcium ion concentration [GO:0051480],
regulation of membrane repolarization [GO:0060306],
membrane organization [GO:0061024],
membrane repolarization during cardiac muscle cell action potential [GO:0086013],
regulation of heart rate by cardiac conduction [GO:0086091],
ciliary basal body docking [GO:0097711],
regulation of postsynaptic specialization membrane neurotransmitter receptor levels [GO:0099072],
regulation of cellular response to heat [GO:1900034],
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740],
regulation of potassium ion transmembrane transporter activity [GO:1901016],
negative regulation of calcium ion transmembrane transporter activity [GO:1901020],
negative regulation of peptidyl-serine dephosphorylation [GO:1902309],
negative regulation of protein dephosphorylation [GO:0035308],

Molecular Function:
RNA binding [GO:0003723],
calcium channel regulator activity [GO:0005246],
protein binding [GO:0005515],
potassium channel regulator activity [GO:0015459],
enzyme binding [GO:0019899],
protein domain specific binding [GO:0019904],
MHC class II protein complex binding [GO:0023026],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
histone deacetylase binding [GO:0042826],
ion channel binding [GO:0044325],
cadherin binding [GO:0045296],
protein heterodimerization activity [GO:0046982],
phosphoserine binding [GO:0050815],
phosphoprotein binding [GO:0051219],
scaffold protein binding [GO:0097110],
protein phosphatase binding [GO:0019903],
macromolecular complex binding [GO:0044877],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
kinesin complex [GO:0005871],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
membrane [GO:0016020],
melanosome [GO:0042470],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
axon [GO:0030424],
synapse [GO:0045202],