YAP1

Yes1 associated transcriptional regulator

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27358050 MEF, hepatocyte, hepatoblast Human, mouse NO
30755404 OSEs Human NO
31155496 Primary β cells derived from pancreas Mouse YES
31935369 PC-9, HCC827, HCC4006, DFCI243 Human NO
33314583 HUVECs Vessels Human NO
33314583 HUVECs Vessels mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
22068052 HCT 116 Human NO
26496700 RD, SMS-CTR Mouse NO
29318697 LO2 Liver Human, mouse NO
29650681 MDA-MB-231, IMR-90, MCF1A-MII, WI-38 Human NO
29901163 A549 Human NO
30123063 PDLSC Human NO
30389502 A549, H1299, Calu6, H52, HBEC Human NO
32991321 C6 ATCC Human NO
33495462 SW 1353 Human No
33495462 Hs 819.T Human No
33495462 U-2 OS Human No
32570219 Primary fibroblasts derived from skin Human NO
32570219 Primary fibroblasts derived from skin mouse NO

GO terms:

Biological Process:
cell morphogenesis [GO:0000902],
vasculogenesis [GO:0001570],
tissue homeostasis [GO:0001894],
heart process [GO:0003015],
embryonic heart tube morphogenesis [GO:0003143],
transcription initiation from RNA polymerase II promoter [GO:0006367],
cellular response to DNA damage stimulus [GO:0006974],
cell proliferation [GO:0008283],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
regulation of keratinocyte proliferation [GO:0010837],
keratinocyte differentiation [GO:0030216],
negative regulation of epithelial cell differentiation [GO:0030857],
notochord development [GO:0030903],
response to progesterone [GO:0032570],
positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148],
somatic stem cell population maintenance [GO:0035019],
hippo signaling [GO:0035329],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
paraxial mesoderm development [GO:0048339],
lateral mesoderm development [GO:0048368],
positive regulation of epithelial cell proliferation [GO:0050679],
regulation of neurogenesis [GO:0050767],
progesterone receptor signaling pathway [GO:0050847],
positive regulation of cardiac muscle cell proliferation [GO:0060045],
contact inhibition [GO:0060242],
bud elongation involved in lung branching [GO:0060449],
lung epithelial cell differentiation [GO:0060487],
cardiac muscle tissue regeneration [GO:0061026],
macromolecular complex assembly [GO:0065003],
cellular response to retinoic acid [GO:0071300],
cellular response to gamma radiation [GO:0071480],
regulation of stem cell proliferation [GO:0072091],
regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
regulation of hematopoietic stem cell differentiation [GO:1902036],
positive regulation of stem cell population maintenance [GO:1902459],
negative regulation of nucleic acid-templated transcription [GO:1903507],
negative regulation of epithelial cell apoptotic process [GO:1904036],
negative regulation of stem cell differentiation [GO:2000737],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],
blastocyst development [GO:0001824],
trophectodermal cell differentiation [GO:0001829],
positive regulation of cell proliferation [GO:0008284],
regulation of gene expression [GO:0010468],
regulation of cell proliferation [GO:0042127],
positive regulation of organ growth [GO:0046622],
regulation of canonical Wnt signaling pathway [GO:0060828],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
chromatin binding [GO:0003682],
transcription coactivator activity [GO:0003713],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
protein C-terminus binding [GO:0008022],
proline-rich region binding [GO:0070064],
transcription factor binding [GO:0008134],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
membrane [GO:0016020],
TEAD-1-YAP complex [GO:0071148],
TEAD-2-YAP complex [GO:0071149],
female germ cell nucleus [GO:0001674],
transcription factor complex [GO:0005667],