XDH

xanthine dehydrogenase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
HBEC Human NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
negative regulation of protein phosphorylation [GO:0001933],
negative regulation of endothelial cell proliferation [GO:0001937],
purine nucleotide catabolic process [GO:0006195],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
lactation [GO:0007595],
xanthine catabolic process [GO:0009115],
negative regulation of gene expression [GO:0010629],
electron transport chain [GO:0022900],
negative regulation of endothelial cell differentiation [GO:0045602],
negative regulation of protein kinase B signaling [GO:0051898],
positive regulation of p38MAPK cascade [GO:1900745],
negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747],
positive regulation of reactive oxygen species metabolic process [GO:2000379],
negative regulation of vasculogenesis [GO:2001213],
hypoxanthine oxidation [GO:0006150],
response to aluminum ion [GO:0010044],
regulation of epithelial cell differentiation [GO:0030856],
oxidation-reduction process [GO:0055114],

Molecular Function:
xanthine dehydrogenase activity [GO:0004854],
xanthine oxidase activity [GO:0004855],
iron ion binding [GO:0005506],
electron carrier activity [GO:0009055],
protein homodimerization activity [GO:0042803],
molybdopterin cofactor binding [GO:0043546],
flavin adenine dinucleotide binding [GO:0050660],
2 iron, 2 sulfur cluster binding [GO:0051537],
FAD binding [GO:0071949],
protein binding [GO:0005515],
oxidoreductase activity [GO:0016491],
molybdenum ion binding [GO:0030151],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],
nitrite reductase (NO-forming) activity [GO:0050421],
iron-sulfur cluster binding [GO:0051536],

Cellular Component:
extracellular space [GO:0005615],
peroxisome [GO:0005777],
cytosol [GO:0005829],
sarcoplasmic reticulum [GO:0016529],
extracellular region [GO:0005576],
cytoplasm [GO:0005737],