WWTR1

WW domain containing transcription regulator 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28613007 Primary cells derived from testis, TM3 Testis Mouse NO
31983656 MSC Human YES
33495462 SW 1353 Human No

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
osteoblast differentiation [GO:0001649],
tissue homeostasis [GO:0001894],
negative regulation of protein phosphorylation [GO:0001933],
heart process [GO:0003015],
regulation of transcription, DNA-templated [GO:0006355],
transcription initiation from RNA polymerase II promoter [GO:0006367],
negative regulation of protein kinase activity [GO:0006469],
positive regulation of cell proliferation [GO:0008284],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
protein ubiquitination [GO:0016567],
stem cell division [GO:0017145],
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146],
glomerulus development [GO:0032835],
multicellular organism growth [GO:0035264],
hippo signaling [GO:0035329],
negative regulation of fat cell differentiation [GO:0045599],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
mesenchymal cell differentiation [GO:0048762],
cilium assembly [GO:0060271],
regulation of SMAD protein import into nucleus [GO:0060390],
kidney morphogenesis [GO:0060993],
regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
regulation of canonical Wnt signaling pathway [GO:0060828],

Molecular Function:
transcription coactivator activity [GO:0003713],
transcription corepressor activity [GO:0003714],
protein binding [GO:0005515],
protein homodimerization activity [GO:0042803],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
transcription factor complex [GO:0005667],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
nuclear body [GO:0016604],