WW domain containing E3 ubiquitin protein ligase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF, HCA738 Skin, Lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
21795702 2BS, WI-38, HeLa Human NO

GO terms:

Biological Process:
protein polyubiquitination [GO:0000209],
ubiquitin-dependent protein catabolic process [GO:0006511],
signal transduction [GO:0007165],
central nervous system development [GO:0007417],
protein ubiquitination [GO:0016567],
ion transmembrane transport [GO:0034220],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
positive regulation of protein catabolic process [GO:0045732],
negative regulation of transcription, DNA-templated [GO:0045892],
viral entry into host cell [GO:0046718],
T cell differentiation [GO:0030217],
lung development [GO:0030324],

Molecular Function:
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
ubiquitin protein ligase activity [GO:0061630],
transferase activity [GO:0016740],

Cellular Component:
ubiquitin ligase complex [GO:0000151],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
extracellular exosome [GO:0070062],
membrane [GO:0016020],