WNT5A

Wnt family member 5A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21816908 OVCAR5, HOSE Human NO
28100769 HDF Human NO
31945125 Primary astrocytes derived from brain Human YES
31964233 Primary mesenchymal stem cells derived from synovium Human NO

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
establishment of planar polarity [GO:0001736],
somitogenesis [GO:0001756],
epithelial to mesenchymal transition [GO:0001837],
positive regulation of endothelial cell proliferation [GO:0001938],
heart looping [GO:0001947],
positive regulation of mesenchymal cell proliferation [GO:0002053],
lens development in camera-type eye [GO:0002088],
positive regulation of cytokine production involved in immune response [GO:0002720],
primary heart field specification [GO:0003138],
secondary heart field specification [GO:0003139],
atrial septum development [GO:0003283],
type B pancreatic cell development [GO:0003323],
planar cell polarity pathway involved in axis elongation [GO:0003402],
optic cup formation involved in camera-type eye development [GO:0003408],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
activation of JUN kinase activity [GO:0007257],
axon guidance [GO:0007411],
hindgut morphogenesis [GO:0007442],
midgut development [GO:0007494],
male gonad development [GO:0008584],
anterior/posterior axis specification, embryo [GO:0008595],
response to organic substance [GO:0010033],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of gene expression [GO:0010628],
positive regulation of peptidyl-threonine phosphorylation [GO:0010800],
positive regulation of T cell chemotaxis [GO:0010820],
positive regulation of neuron projection development [GO:0010976],
Wnt signaling pathway [GO:0016055],
olfactory bulb interneuron development [GO:0021891],
neuron differentiation [GO:0030182],
keratinocyte differentiation [GO:0030216],
lung development [GO:0030324],
negative regulation of BMP signaling pathway [GO:0030514],
positive regulation of protein binding [GO:0032092],
activation of protein kinase B activity [GO:0032148],
positive regulation of interferon-gamma production [GO:0032729],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
cellular protein localization [GO:0034613],
non-canonical Wnt signaling pathway [GO:0035567],
post-anal tail morphogenesis [GO:0036342],
chemoattraction of serotonergic neuron axon [GO:0036517],
chemorepulsion of dopaminergic neuron axon [GO:0036518],
non-canonical Wnt signaling pathway via JNK cascade [GO:0038031],
negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037],
wound healing [GO:0042060],
embryonic digit morphogenesis [GO:0042733],
positive regulation of macrophage activation [GO:0043032],
negative regulation of apoptotic process [GO:0043066],
regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122],
positive regulation of chemokine biosynthetic process [GO:0045080],
cell fate commitment [GO:0045165],
establishment of epithelial cell apical/basal polarity [GO:0045198],
negative regulation of fat cell differentiation [GO:0045599],
positive regulation of protein catabolic process [GO:0045732],
positive regulation of angiogenesis [GO:0045766],
positive regulation of ossification [GO:0045778],
positive regulation of endocytosis [GO:0045807],
positive regulation of meiotic nuclear division [GO:0045836],
negative regulation of transcription, DNA-templated [GO:0045892],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of melanin biosynthetic process [GO:0048022],
positive regulation of fibroblast proliferation [GO:0048146],
paraxial mesoderm formation [GO:0048341],
notochord morphogenesis [GO:0048570],
embryonic skeletal system development [GO:0048706],
genitalia development [GO:0048806],
negative regulation of axon extension involved in axon guidance [GO:0048843],
hypophysis morphogenesis [GO:0048850],
negative regulation of epithelial cell proliferation [GO:0050680],
positive regulation of interleukin-1 beta secretion [GO:0050718],
regulation of inflammatory response [GO:0050727],
positive regulation of inflammatory response [GO:0050729],
regulation of synapse organization [GO:0050807],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
cartilage development [GO:0051216],
positive regulation of anagen [GO:0051885],
negative regulation of synapse assembly [GO:0051964],
convergent extension involved in axis elongation [GO:0060028],
convergent extension involved in organogenesis [GO:0060029],
uterus development [GO:0060065],
cervix development [GO:0060067],
vagina development [GO:0060068],
canonical Wnt signaling pathway [GO:0060070],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
urinary bladder development [GO:0060157],
face development [GO:0060324],
positive regulation of type I interferon-mediated signaling pathway [GO:0060340],
lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599],
mesenchymal-epithelial cell signaling [GO:0060638],
negative regulation of prostatic bud formation [GO:0060686],
mammary gland branching involved in thelarche [GO:0060744],
epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750],
positive regulation of response to cytokine stimulus [GO:0060760],
regulation of branching involved in mammary gland duct morphogenesis [GO:0060762],
planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775],
mesodermal to mesenchymal transition involved in gastrulation [GO:0060809],
positive regulation of macrophage cytokine production [GO:0060907],
membrane organization [GO:0061024],
positive regulation of cartilage development [GO:0061036],
planar cell polarity pathway involved in outflow tract morphogenesis [GO:0061347],
planar cell polarity pathway involved in ventricular septum morphogenesis [GO:0061348],
planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:0061349],
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:0061350],
planar cell polarity pathway involved in pericardium morphogenesis [GO:0061354],
positive regulation of thymocyte apoptotic process [GO:0070245],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to calcium ion [GO:0071277],
cellular response to retinoic acid [GO:0071300],
cellular response to interferon-gamma [GO:0071346],
hematopoietic stem cell proliferation [GO:0071425],
cellular response to transforming growth factor beta stimulus [GO:0071560],
negative regulation of mesenchymal cell proliferation [GO:0072201],
primitive streak formation [GO:0090009],
positive regulation of protein kinase C signaling [GO:0090037],
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [GO:0090082],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
cochlea morphogenesis [GO:0090103],
planar cell polarity pathway involved in neural tube closure [GO:0090179],
activation of GTPase activity [GO:0090630],
melanocyte proliferation [GO:0097325],
presynapse assembly [GO:0099054],
postsynapse assembly [GO:0099068],
regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566],
positive regulation of protein kinase C activity [GO:1900020],
positive regulation of neuron death [GO:1901216],
positive regulation of protein localization to synapse [GO:1902474],
regulation of cellular protein localization [GO:1903827],
positive regulation of tumor necrosis factor secretion [GO:1904469],
excitatory synapse assembly [GO:1904861],
inhibitory synapse assembly [GO:1904862],
negative regulation of cell proliferation in midbrain [GO:1904934],
planar cell polarity pathway involved in axon guidance [GO:1904938],
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953],
planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation [GO:1904955],
positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049],
positive regulation of non-canonical Wnt signaling pathway [GO:2000052],
positive regulation of interleukin-8 secretion [GO:2000484],
ameboidal-type cell migration [GO:0001667],
positive regulation of cytokine production [GO:0001819],
neural tube closure [GO:0001843],
positive regulation of protein phosphorylation [GO:0001934],
morphogenesis of an epithelium [GO:0002009],
ventricular septum development [GO:0003281],
pericardium morphogenesis [GO:0003344],
axis elongation [GO:0003401],
protein phosphorylation [GO:0006468],
signal transduction [GO:0007165],
JNK cascade [GO:0007254],
cell-cell signaling [GO:0007267],
multicellular organism development [GO:0007275],
determination of left/right symmetry [GO:0007368],
axonogenesis [GO:0007409],
axonal fasciculation [GO:0007413],
positive regulation of cell proliferation [GO:0008284],
embryo development [GO:0009790],
animal organ morphogenesis [GO:0009887],
anterior/posterior pattern specification [GO:0009952],
cell migration [GO:0016477],
neural tube development [GO:0021915],
neurogenesis [GO:0022008],
positive regulation of cell-cell adhesion [GO:0022409],
cell differentiation [GO:0030154],
embryonic limb morphogenesis [GO:0030326],
midbrain development [GO:0030901],
regulation of protein localization [GO:0032880],
limb morphogenesis [GO:0035108],
inner ear morphogenesis [GO:0042472],
positive regulation of JUN kinase activity [GO:0043507],
positive regulation of GTPase activity [GO:0043547],
positive regulation of protein kinase activity [GO:0045860],
positive regulation of JNK cascade [GO:0046330],
development of primary male sexual characteristics [GO:0046546],
digestive tract morphogenesis [GO:0048546],
neuron projection morphogenesis [GO:0048812],
positive regulation of epithelial cell proliferation [GO:0050679],
negative chemotaxis [GO:0050919],
convergent extension [GO:0060026],
tube closure [GO:0060606],
somite development [GO:0061053],
cellular response to molecule of bacterial origin [GO:0071219],
dopaminergic neuron differentiation [GO:0071542],
midbrain dopaminergic neuron differentiation [GO:1904948],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
frizzled binding [GO:0005109],
receptor tyrosine kinase-like orphan receptor binding [GO:0005115],
cytokine activity [GO:0005125],
protein binding [GO:0005515],
phospholipid binding [GO:0005543],
protein domain specific binding [GO:0019904],
receptor agonist activity [GO:0048018],
chemoattractant activity involved in axon guidance [GO:1902379],
receptor binding [GO:0005102],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
Golgi lumen [GO:0005796],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
clathrin-coated vesicle membrane [GO:0030665],
endocytic vesicle membrane [GO:0030666],
clathrin-coated endocytic vesicle membrane [GO:0030669],
extracellular exosome [GO:0070062],
postsynapse [GO:0098794],
glutamatergic synapse [GO:0098978],
cytoplasm [GO:0005737],
extracellular matrix [GO:0031012],