WNK1

WNK lysine deficient protein kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of sodium ion transport [GO:0002028],
protein phosphorylation [GO:0006468],
negative regulation of protein kinase activity [GO:0006469],
ion transport [GO:0006811],
negative regulation of sodium ion transport [GO:0010766],
positive regulation of T cell chemotaxis [GO:0010820],
negative regulation of phosphatase activity [GO:0010923],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
signal transduction by trans-phosphorylation [GO:0023016],
activation of protein kinase activity [GO:0032147],
positive regulation of ion transmembrane transporter activity [GO:0032414],
negative regulation of cell-cell adhesion mediated by integrin [GO:0033633],
negative regulation of heterotypic cell-cell adhesion [GO:0034115],
negative regulation of GTPase activity [GO:0034260],
intracellular signal transduction [GO:0035556],
chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116],
neuron development [GO:0048666],
regulation of cellular process [GO:0050794],
ion homeostasis [GO:0050801],
T cell receptor signaling pathway [GO:0050852],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
lymphocyte migration into lymph node [GO:0097022],
negative regulation of leukocyte cell-cell adhesion [GO:1903038],
positive regulation of potassium ion import [GO:1903288],
regulation of cation transmembrane transport [GO:1904062],
cellular response to chemokine [GO:1990869],
positive regulation of sodium ion transmembrane transporter activity [GO:2000651],
positive regulation of systemic arterial blood pressure [GO:0003084],
phosphorylation [GO:0016310],
negative regulation of kinase activity [GO:0033673],
protein autophosphorylation [GO:0046777],
cellular response to calcium ion [GO:0071277],
negative regulation of pancreatic juice secretion [GO:0090188],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein kinase inhibitor activity [GO:0004860],
protein binding [GO:0005515],
ATP binding [GO:0005524],
chloride channel inhibitor activity [GO:0019869],
potassium channel inhibitor activity [GO:0019870],
protein kinase binding [GO:0019901],
phosphatase binding [GO:0019902],
protein kinase activator activity [GO:0030295],
nucleotide binding [GO:0000166],
magnesium ion binding [GO:0000287],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
protein serine/threonine kinase inhibitor activity [GO:0030291],

Cellular Component:
cytoplasm [GO:0005737],
cytosol [GO:0005829],
membrane [GO:0016020],