WIPI2

WD repeat domain, phosphoinositide interacting 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30898011 HeLa Human NO
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
protein lipidation [GO:0006497],
cellular response to starvation [GO:0009267],
macroautophagy [GO:0016236],
protein localization to pre-autophagosomal structure [GO:0034497],
nucleophagy [GO:0044804],
protein lipidation involved in autophagosome assembly [GO:0061739],
autophagosome maturation [GO:0097352],
xenophagy [GO:0098792],
autophagy [GO:0006914],

Molecular Function:
protein binding [GO:0005515],
phosphatidylinositol-3-phosphate binding [GO:0032266],
phosphatidylinositol-3,5-bisphosphate binding [GO:0080025],
lipid binding [GO:0008289],
phosphatidylinositol-5-phosphate binding [GO:0010314],

Cellular Component:
pre-autophagosomal structure [GO:0000407],
nucleoplasm [GO:0005654],
autophagosome [GO:0005776],
cytosol [GO:0005829],
membrane [GO:0016020],
extrinsic component of membrane [GO:0019898],
macromolecular complex [GO:0032991],
pre-autophagosomal structure membrane [GO:0034045],