WIPI1

WD repeat domain, phosphoinositide interacting 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
mitophagy [GO:0000422],
protein lipidation [GO:0006497],
autophagy [GO:0006914],
cellular response to starvation [GO:0009267],
protein localization to pre-autophagosomal structure [GO:0034497],
nucleophagy [GO:0044804],
vesicle targeting, trans-Golgi to endosome [GO:0048203],
macroautophagy [GO:0016236],
IRE1-mediated unfolded protein response [GO:0036498],

Molecular Function:
receptor binding [GO:0005102],
lipid binding [GO:0008289],
estrogen receptor binding [GO:0030331],
phosphatidylinositol-3-phosphate binding [GO:0032266],
androgen receptor binding [GO:0050681],
phosphatidylinositol-3,5-bisphosphate binding [GO:0080025],
protein binding [GO:0005515],

Cellular Component:
pre-autophagosomal structure [GO:0000407],
autophagosome membrane [GO:0000421],
cytoplasm [GO:0005737],
endosome [GO:0005768],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
endosome membrane [GO:0010008],
membrane [GO:0016020],
extrinsic component of membrane [GO:0019898],
cytoplasmic vesicle [GO:0031410],
pre-autophagosomal structure membrane [GO:0034045],
Golgi membrane [GO:0000139],
clathrin-coated vesicle [GO:0030136],