WASL

WASP like actin nucleation promoting factor

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30894371 Primary keratinocytes Skin Mouse NO

GO terms:

Biological Process:
membrane budding [GO:0006900],
actin polymerization or depolymerization [GO:0008154],
response to bacterium [GO:0009617],
vesicle organization [GO:0016050],
actin filament polymerization [GO:0030041],
actin filament-based movement [GO:0030048],
vesicle transport along actin filament [GO:0030050],
regulation of protein localization [GO:0032880],
cellular protein complex localization [GO:0034629],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
ephrin receptor signaling pathway [GO:0048013],
regulation of nitric-oxide synthase activity [GO:0050999],
cell division [GO:0051301],
positive regulation of filopodium assembly [GO:0051491],
spindle localization [GO:0051653],
dendritic spine morphogenesis [GO:0060997],
membrane organization [GO:0061024],
macromolecular complex assembly [GO:0065003],
negative regulation of membrane tubulation [GO:1903526],
positive regulation of clathrin-dependent endocytosis [GO:2000370],
negative regulation of lymphocyte migration [GO:2000402],
positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601],
actin filament organization [GO:0007015],
cell cycle [GO:0007049],
membrane invagination [GO:0010324],
cell projection assembly [GO:0030031],
actin cytoskeleton organization [GO:0030036],
actin nucleation [GO:0045010],
membrane tubulation [GO:0097320],
postsynaptic actin cytoskeleton organization [GO:0098974],

Molecular Function:
protein binding [GO:0005515],
GTPase regulator activity [GO:0030695],
actin binding [GO:0003779],
cytoskeletal protein binding [GO:0008092],
identical protein binding [GO:0042802],

Cellular Component:
nucleus [GO:0005634],
cytosol [GO:0005829],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
actin cytoskeleton [GO:0015629],
lamellipodium [GO:0030027],
actin cap [GO:0030478],
endocytic vesicle membrane [GO:0030666],
cytoplasmic vesicle [GO:0031410],
extracellular exosome [GO:0070062],
Golgi membrane [GO:0000139],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
cell leading edge [GO:0031252],
postsynapse [GO:0098794],
glutamatergic synapse [GO:0098978],