VPS4B

vacuolar protein sorting 4 homolog B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
potassium ion transport [GO:0006813],
nucleus organization [GO:0006997],
mitotic metaphase plate congression [GO:0007080],
regulation of centrosome duplication [GO:0010824],
positive regulation of G2/M transition of mitotic cell cycle [GO:0010971],
protein transport [GO:0015031],
endosomal transport [GO:0016197],
macroautophagy [GO:0016236],
viral life cycle [GO:0019058],
viral release from host cell [GO:0019076],
cholesterol transport [GO:0030301],
cytoplasmic microtubule organization [GO:0031122],
endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510],
response to lipid [GO:0033993],
multivesicular body assembly [GO:0036258],
viral budding via host ESCRT complex [GO:0039702],
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162],
positive regulation of viral process [GO:0048524],
regulation of viral process [GO:0050792],
protein depolymerization [GO:0051261],
negative regulation of cell death [GO:0060548],
late endosomal microautophagy [GO:0061738],
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611],
regulation of mitotic spindle assembly [GO:1901673],
positive regulation of viral release from host cell [GO:1902188],
negative regulation of exosomal secretion [GO:1903542],
positive regulation of exosomal secretion [GO:1903543],
positive regulation of centriole elongation [GO:1903724],
positive regulation of viral life cycle [GO:1903902],
ESCRT III complex disassembly [GO:1904903],
endosome organization [GO:0007032],
cell cycle [GO:0007049],
cell division [GO:0051301],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
microtubule-severing ATPase activity [GO:0008568],
ATPase activity [GO:0016887],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
macromolecular complex binding [GO:0044877],
nucleotide binding [GO:0000166],
hydrolase activity [GO:0016787],

Cellular Component:
spindle pole [GO:0000922],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endosome [GO:0005768],
centrosome [GO:0005813],
cytosol [GO:0005829],
endosome membrane [GO:0010008],
late endosome membrane [GO:0031902],
extracellular exosome [GO:0070062],
Flemming body [GO:0090543],
membrane [GO:0016020],