VPS4A

vacuolar protein sorting 4 homolog A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
actomyosin contractile ring contraction [GO:0000916],
protein targeting to lysosome [GO:0006622],
membrane budding [GO:0006900],
nucleus organization [GO:0006997],
nuclear envelope organization [GO:0006998],
vacuole organization [GO:0007033],
mitotic metaphase plate congression [GO:0007080],
abscission [GO:0009838],
vesicle-mediated transport [GO:0016192],
endosomal transport [GO:0016197],
macroautophagy [GO:0016236],
viral life cycle [GO:0019058],
viral release from host cell [GO:0019076],
nuclear envelope reassembly [GO:0031468],
intracellular cholesterol transport [GO:0032367],
negative regulation of cytokinesis [GO:0032466],
regulation of protein localization [GO:0032880],
endosomal vesicle fusion [GO:0034058],
multivesicular body assembly [GO:0036258],
viral budding via host ESCRT complex [GO:0039702],
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162],
mitotic cytokinesis checkpoint [GO:0044878],
cell division [GO:0051301],
cytoskeleton-dependent cytokinesis [GO:0061640],
late endosomal microautophagy [GO:0061738],
vesicle uncoating [GO:0072319],
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611],
positive regulation of viral release from host cell [GO:1902188],
regulation of protein localization to plasma membrane [GO:1903076],
positive regulation of exosomal secretion [GO:1903543],
positive regulation of viral budding via host ESCRT complex [GO:1903774],
positive regulation of viral life cycle [GO:1903902],
ESCRT complex disassembly [GO:1904896],
ESCRT III complex disassembly [GO:1904903],
cell cycle [GO:0007049],
protein transport [GO:0015031],
positive regulation of viral process [GO:0048524],

Molecular Function:
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
ATPase activity [GO:0016887],
protein domain specific binding [GO:0019904],
macromolecular complex binding [GO:0044877],
nucleotide binding [GO:0000166],
hydrolase activity [GO:0016787],
Rho GTPase binding [GO:0017048],

Cellular Component:
spindle pole [GO:0000922],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
endosome [GO:0005768],
early endosome [GO:0005769],
late endosome [GO:0005770],
vacuolar membrane [GO:0005774],
centrosome [GO:0005813],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
endosome membrane [GO:0010008],
midbody [GO:0030496],
late endosome membrane [GO:0031902],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
Flemming body [GO:0090543],
membrane [GO:0016020],