VPS11 core subunit of CORVET and HOPS complexes

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
intracellular protein transport [GO:0006886],
vesicle docking involved in exocytosis [GO:0006904],
autophagy [GO:0006914],
endosome organization [GO:0007032],
vacuole organization [GO:0007033],
endosome to lysosome transport [GO:0008333],
regulation of protein stability [GO:0031647],
endosomal vesicle fusion [GO:0034058],
regulation of SNARE complex assembly [GO:0035542],
regulation of organelle assembly [GO:1902115],
positive regulation of cellular protein catabolic process [GO:1903364],
positive regulation of protein targeting to mitochondrion [GO:1903955],
positive regulation of early endosome to late endosome transport [GO:2000643],
protein transport [GO:0015031],
vesicle-mediated transport [GO:0016192],
toxin transport [GO:1901998],

Molecular Function:
nucleotide binding [GO:0000166],
protein binding [GO:0005515],
protein domain specific binding [GO:0019904],
syntaxin binding [GO:0019905],
protein binding, bridging [GO:0030674],
metal ion binding [GO:0046872],

Cellular Component:
lysosome [GO:0005764],
lysosomal membrane [GO:0005765],
endosome [GO:0005768],
early endosome [GO:0005769],
late endosome [GO:0005770],
autophagosome [GO:0005776],
clathrin-coated vesicle [GO:0030136],
endocytic vesicle [GO:0030139],
HOPS complex [GO:0030897],
late endosome membrane [GO:0031902],
actin filament [GO:0005884],
membrane [GO:0016020],
AP-3 adaptor complex [GO:0030123],
cytoplasmic vesicle [GO:0031410],
CORVET complex [GO:0033263],
presynaptic active zone [GO:0048786],