VEGFA

vascular endothelial growth factor A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15247002 HUVEC Human NO
24960204 Primary fibroblasts Mouse NO
30988157 IMR-90 Human YES
31124078 Primary fibroblasts derived from foreskin, G08, G09 Human NO
31183403 IMR-90 Human YES
31186408 OV-90,OV-1369, OV-1946 Human YES
31239406 Primary epithelial cells derived from intensine Intensine Mouse NO
31687975 IMR-90 Human YES
31971661 Primary mesenchymal stem cells derived from adipose tissue Mouse YES
33053897 Primary stemm cells derived from adipose tissue Human No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28634450 HUVEC Human, rat NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31155496 Primary β cells derived from pancreas Mouse YES
31945125 Primary astrocytes derived from brain Human YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
angiogenesis [GO:0001525],
ovarian follicle development [GO:0001541],
patterning of blood vessels [GO:0001569],
vasculogenesis [GO:0001570],
response to hypoxia [GO:0001666],
in utero embryonic development [GO:0001701],
kidney development [GO:0001822],
positive regulation of protein phosphorylation [GO:0001934],
positive regulation of endothelial cell proliferation [GO:0001938],
sprouting angiogenesis [GO:0002040],
cell migration involved in sprouting angiogenesis [GO:0002042],
positive regulation of neuroblast proliferation [GO:0002052],
positive regulation of mesenchymal cell proliferation [GO:0002053],
positive regulation of receptor internalization [GO:0002092],
platelet degranulation [GO:0002576],
positive regulation of leukocyte migration [GO:0002687],
heart morphogenesis [GO:0003007],
outflow tract morphogenesis [GO:0003151],
coronary vein morphogenesis [GO:0003169],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
nervous system development [GO:0007399],
mesoderm development [GO:0007498],
lactation [GO:0007595],
positive regulation of cell proliferation [GO:0008284],
regulation of cell shape [GO:0008360],
positive regulation of endothelial cell migration [GO:0010595],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
regulation of nitric oxide mediated signal transduction [GO:0010749],
cytokine-mediated signaling pathway [GO:0019221],
monocyte differentiation [GO:0030224],
macrophage differentiation [GO:0030225],
lung development [GO:0030324],
positive regulation of cell migration [GO:0030335],
epithelial cell differentiation [GO:0030855],
post-embryonic camera-type eye development [GO:0031077],
positive regulation of protein complex assembly [GO:0031334],
positive regulation of protein autophosphorylation [GO:0031954],
activation of protein kinase activity [GO:0032147],
positive regulation of CREB transcription factor activity [GO:0032793],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
tube formation [GO:0035148],
endothelial cell chemotaxis [GO:0035767],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
lymph vessel morphogenesis [GO:0036303],
vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324],
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033],
vascular endothelial growth factor signaling pathway [GO:0038084],
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091],
VEGF-activated neuropilin signaling pathway [GO:0038190],
eye photoreceptor cell development [GO:0042462],
positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531],
negative regulation of apoptotic process [GO:0043066],
positive regulation of vascular permeability [GO:0043117],
surfactant homeostasis [GO:0043129],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of angiogenesis [GO:0045766],
positive regulation of cell adhesion [GO:0045785],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
cell maturation [GO:0048469],
camera-type eye morphogenesis [GO:0048593],
cardiac muscle fiber development [GO:0048739],
branching morphogenesis of an epithelial tube [GO:0048754],
positive regulation of axon extension involved in axon guidance [GO:0048842],
artery morphogenesis [GO:0048844],
positive regulation of epithelial cell proliferation [GO:0050679],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
positive chemotaxis [GO:0050918],
positive regulation of positive chemotaxis [GO:0050927],
induction of positive chemotaxis [GO:0050930],
positive regulation of cellular component movement [GO:0051272],
positive regulation of cell division [GO:0051781],
positive regulation of focal adhesion assembly [GO:0051894],
primitive erythrocyte differentiation [GO:0060319],
mammary gland alveolus development [GO:0060749],
positive regulation of mast cell chemotaxis [GO:0060754],
cardiac vascular smooth muscle cell development [GO:0060948],
coronary artery morphogenesis [GO:0060982],
vascular wound healing [GO:0061042],
regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418],
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419],
cellular response to hypoxia [GO:0071456],
dopaminergic neuron differentiation [GO:0071542],
commissural neuron axon guidance [GO:0071679],
positive regulation of protein kinase C signaling [GO:0090037],
positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050],
positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190],
regulation of retinal ganglion cell axon guidance [GO:0090259],
motor neuron migration [GO:0097475],
cellular stress response to acid chemical [GO:0097533],
positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086],
positive regulation of p38MAPK cascade [GO:1900745],
positive regulation of trophoblast cell migration [GO:1901165],
positive regulation of histone deacetylase activity [GO:1901727],
positive regulation of retinal ganglion cell axon guidance [GO:1902336],
negative regulation of establishment of endothelial barrier [GO:1903141],
negative regulation of adherens junction organization [GO:1903392],
positive regulation of protein kinase D signaling [GO:1903572],
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589],
positive regulation of sprouting angiogenesis [GO:1903672],
negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048],
blood vessel development [GO:0001568],
vasculature development [GO:0001944],
lymphangiogenesis [GO:0001946],
blood vessel remodeling [GO:0001974],
basophil chemotaxis [GO:0002575],
multicellular organism development [GO:0007275],
cell proliferation [GO:0008283],
positive regulation of signal transduction [GO:0009967],
negative regulation of epithelial to mesenchymal transition [GO:0010719],
cell migration [GO:0016477],
negative regulation of cell-cell adhesion [GO:0022408],
cell differentiation [GO:0030154],
regulation of growth [GO:0040008],
T-helper 1 type immune response [GO:0042088],
positive regulation of phosphorylation [GO:0042327],
negative regulation of programmed cell death [GO:0043069],
negative regulation of neuron apoptotic process [GO:0043524],
endothelial cell migration [GO:0043542],
negative regulation of fat cell differentiation [GO:0045599],
regulation of endothelial cell differentiation [GO:0045601],
positive regulation of osteoblast differentiation [GO:0045669],
negative regulation of bone resorption [GO:0045779],
mRNA stabilization [GO:0048255],
lung alveolus development [GO:0048286],
blood vessel morphogenesis [GO:0048514],
positive regulation of smooth muscle cell proliferation [GO:0048661],
neuron development [GO:0048666],
homeostasis of number of cells within a tissue [GO:0048873],
positive regulation of protein kinase B signaling [GO:0051897],
cell chemotaxis [GO:0060326],
bone trabecula formation [GO:0060346],
lung vasculature development [GO:0060426],
angiogenesis involved in coronary vascular morphogenesis [GO:0060978],
bone trabecula morphogenesis [GO:0061430],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
negative regulation of neuron death [GO:1901215],
positive regulation of lymphangiogenesis [GO:1901492],
regulation of hematopoietic progenitor cell differentiation [GO:1901532],
positive regulation of protein localization to early endosome [GO:1902966],
positive regulation of DNA biosynthetic process [GO:2000573],
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237],

Molecular Function:
fibronectin binding [GO:0001968],
cytokine activity [GO:0005125],
platelet-derived growth factor receptor binding [GO:0005161],
vascular endothelial growth factor receptor binding [GO:0005172],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],
chemoattractant activity [GO:0042056],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
vascular endothelial growth factor receptor 1 binding [GO:0043183],
vascular endothelial growth factor receptor 2 binding [GO:0043184],
receptor agonist activity [GO:0048018],
extracellular matrix binding [GO:0050840],
receptor binding [GO:0005102],
growth factor binding [GO:0019838],
neuropilin binding [GO:0038191],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
adherens junction [GO:0005912],
cell surface [GO:0009986],
membrane [GO:0016020],
secretory granule [GO:0030141],
extracellular matrix [GO:0031012],
platelet alpha granule lumen [GO:0031093],
basement membrane [GO:0005604],
nucleus [GO:0005634],
plasma membrane [GO:0005886],
vesicle [GO:0031982],