VCL

vinculin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
morphogenesis of an epithelium [GO:0002009],
platelet degranulation [GO:0002576],
muscle contraction [GO:0006936],
cell adhesion [GO:0007155],
cell-matrix adhesion [GO:0007160],
lamellipodium assembly [GO:0030032],
negative regulation of cell migration [GO:0030336],
adherens junction assembly [GO:0034333],
protein localization to cell surface [GO:0034394],
maintenance of blood-brain barrier [GO:0035633],
apical junction assembly [GO:0043297],
neutrophil degranulation [GO:0043312],
axon extension [GO:0048675],
regulation of focal adhesion assembly [GO:0051893],
platelet aggregation [GO:0070527],
epithelial cell-cell adhesion [GO:0090136],
regulation of establishment of endothelial barrier [GO:1903140],
regulation of protein localization to cell-cell adherens junction [GO:1904702],
regulation of cell migration [GO:0030334],

Molecular Function:
dystroglycan binding [GO:0002162],
actin binding [GO:0003779],
structural molecule activity [GO:0005198],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
ubiquitin protein ligase binding [GO:0031625],
alpha-catenin binding [GO:0045294],
cadherin binding [GO:0045296],
Rho GTPase binding [GO:0017048],
actin filament binding [GO:0051015],

Cellular Component:
podosome [GO:0002102],
extracellular region [GO:0005576],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
cell-cell junction [GO:0005911],
adherens junction [GO:0005912],
fascia adherens [GO:0005916],
focal adhesion [GO:0005925],
cell-substrate junction [GO:0030055],
macromolecular complex [GO:0032991],
secretory granule lumen [GO:0034774],
specific granule lumen [GO:0035580],
sarcolemma [GO:0042383],
costamere [GO:0043034],
cell-cell contact zone [GO:0044291],
extracellular exosome [GO:0070062],
extracellular vesicle [GO:1903561],
ficolin-1-rich granule lumen [GO:1904813],
stress fiber [GO:0001725],
cytoplasm [GO:0005737],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
intercalated disc [GO:0014704],
actin cytoskeleton [GO:0015629],
membrane [GO:0016020],
Z disc [GO:0030018],
cell junction [GO:0030054],
membrane raft [GO:0045121],