vav guanine nucleotide exchange factor 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
vesicle fusion [GO:0006906],
cellular response to DNA damage stimulus [GO:0006974],
G-protein coupled receptor signaling pathway [GO:0007186],
integrin-mediated signaling pathway [GO:0007229],
small GTPase mediated signal transduction [GO:0007264],
regulation of cell size [GO:0008361],
lamellipodium assembly [GO:0030032],
platelet activation [GO:0030168],
neutrophil chemotaxis [GO:0030593],
positive regulation of B cell proliferation [GO:0030890],
Fc-epsilon receptor signaling pathway [GO:0038095],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
response to drug [GO:0042493],
positive regulation of apoptotic process [GO:0043065],
regulation of GTPase activity [GO:0043087],
positive regulation of GTPase activity [GO:0043547],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
positive regulation of cell adhesion [GO:0045785],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
ephrin receptor signaling pathway [GO:0048013],
B cell receptor signaling pathway [GO:0050853],
regulation of small GTPase mediated signal transduction [GO:0051056],
cell migration [GO:0016477],
cell projection assembly [GO:0030031],
regulation of Rho protein signal transduction [GO:0035023],
intracellular signal transduction [GO:0035556],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
GTPase activator activity [GO:0005096],
epidermal growth factor receptor binding [GO:0005154],
protein binding [GO:0005515],
Rac guanyl-nucleotide exchange factor activity [GO:0030676],
metal ion binding [GO:0046872],
Rho guanyl-nucleotide exchange factor activity [GO:0005089],

Cellular Component:
immunological synapse [GO:0001772],
cytosol [GO:0005829],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],