USP28
ubiquitin specific peptidase 28
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29089421 | BJ, IMR-90 | Human | NO | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 28844647 | BJ, WI-38, IMR-90, MRC-5, HFF, HCA416 | Skin, Lung | Human | YES |
| 29548335 | Li Fraumeni | Human | YES | |
| 31945125 | Primary astrocytes derived from brain | Human | YES | |
GO terms:
Biological Process:
DNA damage checkpoint [GO:0000077],
DNA repair [GO:0006281],
ubiquitin-dependent protein catabolic process [GO:0006511],
cellular response to DNA damage stimulus [GO:0006974],
Ras protein signal transduction [GO:0007265],
cell proliferation [GO:0008283],
response to ionizing radiation [GO:0010212],
protein deubiquitination [GO:0016579],
regulation of protein stability [GO:0031647],
cellular response to UV [GO:0034644],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
Molecular Function:
cysteine-type endopeptidase activity [GO:0004197],
thiol-dependent ubiquitin-specific protease activity [GO:0004843],
protein binding [GO:0005515],
thiol-dependent ubiquitinyl hydrolase activity [GO:0036459],
peptidase activity [GO:0008233],
cysteine-type peptidase activity [GO:0008234],
hydrolase activity [GO:0016787],
Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
nuclear body [GO:0016604],
macromolecular complex [GO:0032991],