USP1

ubiquitin specific peptidase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27160904 BJ Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
skeletal system development [GO:0001501],
regulation of DNA repair [GO:0006282],
ubiquitin-dependent protein catabolic process [GO:0006511],
response to UV [GO:0009411],
protein deubiquitination [GO:0016579],
monoubiquitinated protein deubiquitination [GO:0035520],
interstrand cross-link repair [GO:0036297],
DNA damage response, detection of DNA damage [GO:0042769],
DNA repair [GO:0006281],
proteolysis [GO:0006508],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
cysteine-type endopeptidase activity [GO:0004197],
thiol-dependent ubiquitin-specific protease activity [GO:0004843],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
thiol-dependent ubiquitinyl hydrolase activity [GO:0036459],
cysteine-type peptidase activity [GO:0008234],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],