ULK1

unc-51 like autophagy activating kinase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein phosphorylation [GO:0006468],
autophagy [GO:0006914],
signal transduction [GO:0007165],
protein localization [GO:0008104],
positive regulation of autophagy [GO:0010508],
macroautophagy [GO:0016236],
regulation of macroautophagy [GO:0016241],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
neuron projection regeneration [GO:0031102],
neuron projection development [GO:0031175],
negative regulation of protein complex assembly [GO:0031333],
cellular response to nutrient levels [GO:0031669],
response to starvation [GO:0042594],
protein autophosphorylation [GO:0046777],
axon extension [GO:0048675],
autophagy of host cells involved in interaction with symbiont [GO:0075044],
positive regulation of autophagosome assembly [GO:2000786],
autophagosome assembly [GO:0000045],
macromitophagy [GO:0000423],
Ras protein signal transduction [GO:0007265],
axonogenesis [GO:0007409],
regulation of gene expression [GO:0010468],
regulation of cell death [GO:0010941],
phosphorylation [GO:0016310],
cerebellar granule cell differentiation [GO:0021707],
radial glia guided migration of cerebellar granule cell [GO:0021933],
receptor internalization [GO:0031623],
cellular response to amino acid starvation [GO:0034198],
negative regulation of collateral sprouting [GO:0048671],
regulation of neurotrophin TRK receptor signaling pathway [GO:0051386],
response to mitochondrial depolarisation [GO:0098780],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
Rab GTPase binding [GO:0017137],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
GTPase binding [GO:0051020],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
transferase activity [GO:0016740],
protein kinase binding [GO:0019901],
Hsp90 protein binding [GO:0051879],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrial outer membrane [GO:0005741],
autophagosome [GO:0005776],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
axon [GO:0030424],
guanyl-nucleotide exchange factor complex [GO:0032045],
pre-autophagosomal structure membrane [GO:0034045],
recycling endosome [GO:0055037],
extrinsic component of omegasome membrane [GO:0097629],
extrinsic component of pre-autophagosomal structure membrane [GO:0097632],
extrinsic component of autophagosome membrane [GO:0097635],
ATG1/ULK1 kinase complex [GO:1990316],
pre-autophagosomal structure [GO:0000407],
membrane [GO:0016020],
cytoplasmic vesicle membrane [GO:0030659],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],