ubiquitin conjugating enzyme E2 N

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
activation of MAPK activity [GO:0000187],
protein polyubiquitination [GO:0000209],
double-strand break repair via homologous recombination [GO:0000724],
DNA double-strand break processing [GO:0000729],
regulation of DNA repair [GO:0006282],
postreplication repair [GO:0006301],
double-strand break repair via nonhomologous end joining [GO:0006303],
cellular protein modification process [GO:0006464],
proteolysis [GO:0006508],
JNK cascade [GO:0007254],
protein ubiquitination [GO:0016567],
histone ubiquitination [GO:0016574],
positive regulation of histone modification [GO:0031058],
regulation of histone ubiquitination [GO:0033182],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of DNA repair [GO:0045739],
T cell receptor signaling pathway [GO:0050852],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
positive regulation of ubiquitin-protein transferase activity [GO:0051443],
nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423],
interleukin-1-mediated signaling pathway [GO:0070498],
protein K63-linked ubiquitination [GO:0070534],
DNA repair [GO:0006281],
ubiquitin-dependent protein catabolic process [GO:0006511],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
RNA binding [GO:0003723],
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
ATP binding [GO:0005524],
ubiquitin protein ligase binding [GO:0031625],
ubiquitin binding [GO:0043130],
ubiquitin conjugating enzyme activity [GO:0061631],
nucleotide binding [GO:0000166],
transferase activity [GO:0016740],

Cellular Component:
ubiquitin ligase complex [GO:0000151],
fibrillar center [GO:0001650],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
UBC13-MMS2 complex [GO:0031372],
macromolecular complex [GO:0032991],
UBC13-UEV1A complex [GO:0035370],
extracellular exosome [GO:0070062],