ubiquitin like modifier activating enzyme 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein sumoylation [GO:0016925],
protein modification by small protein conjugation [GO:0032446],
positive regulation of protein sumoylation [GO:0033235],

Molecular Function:
magnesium ion binding [GO:0000287],
protein binding [GO:0005515],
ATP binding [GO:0005524],
transcription factor binding [GO:0008134],
transferase activity [GO:0016740],
SUMO activating enzyme activity [GO:0019948],
SUMO binding [GO:0032183],
small protein activating enzyme binding [GO:0044388],
ubiquitin-like protein conjugating enzyme binding [GO:0044390],
protein heterodimerization activity [GO:0046982],
nucleotide binding [GO:0000166],
small protein activating enzyme activity [GO:0008641],
metal ion binding [GO:0046872],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
SUMO activating enzyme complex [GO:0031510],
nucleus [GO:0005634],