thioredoxin reductase 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
multicellular organism development [GO:0007275],
spermatogenesis [GO:0007283],
electron transport chain [GO:0022900],
cell differentiation [GO:0030154],
cell redox homeostasis [GO:0045454],
cellular oxidant detoxification [GO:0098869],
blastocyst formation [GO:0001825],
glutathione metabolic process [GO:0006749],
oxidation-reduction process [GO:0055114],

Molecular Function:
thioredoxin-disulfide reductase activity [GO:0004791],
electron carrier activity [GO:0009055],
protein disulfide oxidoreductase activity [GO:0015035],
flavin adenine dinucleotide binding [GO:0050660],
protein binding [GO:0005515],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [GO:0016668],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
nucleus [GO:0005634],
intracellular membrane-bounded organelle [GO:0043231],