thioredoxin reductase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
32671444 MDA-MB-231 Breast Human NO
32671444 MDA-MB-231 Breast mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31443378 Primary endothelial cells derived from retina Human NO

GO terms:

Biological Process:
response to oxygen radical [GO:0000305],
cellular response to oxidative stress [GO:0034599],
cell redox homeostasis [GO:0045454],
oxidation-reduction process [GO:0055114],
cellular oxidant detoxification [GO:0098869],
heart development [GO:0007507],
hemopoiesis [GO:0030097],

Molecular Function:
thioredoxin-disulfide reductase activity [GO:0004791],
protein binding [GO:0005515],
flavin adenine dinucleotide binding [GO:0050660],
electron carrier activity [GO:0009055],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [GO:0016668],
protein homodimerization activity [GO:0042803],
macromolecular complex binding [GO:0044877],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial matrix [GO:0005759],
cytosol [GO:0005829],
axon [GO:0030424],
dendrite [GO:0030425],
neuronal cell body [GO:0043025],