thioredoxin reductase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31491600 HAEC Aorta Human, mouse NO

GO terms:

Biological Process:
mesoderm formation [GO:0001707],
selenium compound metabolic process [GO:0001887],
signal transduction [GO:0007165],
cell proliferation [GO:0008283],
nucleobase-containing small molecule interconversion [GO:0015949],
regulation of lipid metabolic process [GO:0019216],
electron transport chain [GO:0022900],
cellular response to oxidative stress [GO:0034599],
cell redox homeostasis [GO:0045454],
cellular oxidant detoxification [GO:0098869],
response to oxidative stress [GO:0006979],
gastrulation [GO:0007369],
positive regulation of cell death [GO:0010942],
selenocysteine metabolic process [GO:0016259],
benzene-containing compound metabolic process [GO:0042537],
hydrogen peroxide catabolic process [GO:0042744],
oxidation-reduction process [GO:0055114],
NADPH oxidation [GO:0070995],

Molecular Function:
thioredoxin-disulfide reductase activity [GO:0004791],
protein binding [GO:0005515],
electron carrier activity [GO:0009055],
protein disulfide oxidoreductase activity [GO:0015035],
flavin adenine dinucleotide binding [GO:0050660],
NAD(P)H oxidase activity [GO:0016174],
oxidoreductase activity [GO:0016491],
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [GO:0016668],
selenate reductase activity [GO:0033797],
identical protein binding [GO:0042802],
mercury ion binding [GO:0045340],

Cellular Component:
fibrillar center [GO:0001650],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
extracellular exosome [GO:0070062],
nucleus [GO:0005634],
mitochondrion [GO:0005739],
neuronal cell body [GO:0043025],