TSC2

TSC complex subunit 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
32439975 ARPE-19 Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
24889617 HT-p21, RPE, NBC, WI-38 Human NO
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES

GO terms:

Biological Process:
neural tube closure [GO:0001843],
negative regulation of protein kinase activity [GO:0006469],
protein import into nucleus [GO:0006606],
endocytosis [GO:0006897],
heart development [GO:0007507],
protein localization [GO:0008104],
negative regulation of cell proliferation [GO:0008285],
negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067],
viral process [GO:0016032],
vesicle-mediated transport [GO:0016192],
positive regulation of macroautophagy [GO:0016239],
regulation of endocytosis [GO:0030100],
negative regulation of Wnt signaling pathway [GO:0030178],
negative regulation of TOR signaling [GO:0032007],
anoikis [GO:0043276],
protein kinase B signaling [GO:0043491],
positive regulation of GTPase activity [GO:0043547],
regulation of insulin receptor signaling pathway [GO:0046626],
negative regulation of insulin receptor signaling pathway [GO:0046627],
insulin-like growth factor receptor signaling pathway [GO:0048009],
positive chemotaxis [GO:0050918],
regulation of small GTPase mediated signal transduction [GO:0051056],
regulation of cell cycle [GO:0051726],
negative regulation of protein kinase B signaling [GO:0051898],
negative regulation of macromitophagy [GO:1901525],
response to hypoxia [GO:0001666],
negative regulation of protein phosphorylation [GO:0001933],
signal transduction [GO:0007165],
aging [GO:0007568],
positive regulation of autophagy [GO:0010508],
negative regulation of epithelial to mesenchymal transition [GO:0010719],
positive regulation of fibroblast migration [GO:0010763],
positive regulation of neuron projection development [GO:0010976],
phosphatidylinositol 3-kinase signaling [GO:0014065],
negative regulation of macroautophagy [GO:0016242],
establishment of cell polarity [GO:0030010],
cell projection organization [GO:0030030],
cellular response to insulin stimulus [GO:0032869],
protein localization to cell surface [GO:0034394],
social behavior [GO:0035176],
negative regulation of MAP kinase activity [GO:0043407],
protein transport into plasma membrane raft [GO:0044861],
establishment of protein localization [GO:0045184],
positive regulation of cell adhesion [GO:0045785],
negative regulation of cell size [GO:0045792],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
glucose import [GO:0046323],
negative regulation of fibroblast proliferation [GO:0048147],
negative regulation of pinocytosis [GO:0048550],
negative regulation of epithelial cell proliferation [GO:0050680],
negative regulation of axonogenesis [GO:0050771],
positive regulation of dendritic spine development [GO:0060999],
negative regulation of TORC1 signaling [GO:1904262],
negative regulation of vascular endothelial cell proliferation [GO:1905563],

Molecular Function:
GTPase activator activity [GO:0005096],
protein binding [GO:0005515],
phosphatase binding [GO:0019902],
small GTPase binding [GO:0031267],
protein homodimerization activity [GO:0042803],
Hsp90 protein binding [GO:0051879],
macromolecular complex binding [GO:0044877],
protein N-terminus binding [GO:0047485],
14-3-3 protein binding [GO:0071889],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
lysosome [GO:0005764],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
TSC1-TSC2 complex [GO:0033596],
perinuclear region of cytoplasm [GO:0048471],
cytoskeleton [GO:0005856],
caveola [GO:0005901],
dendrite [GO:0030425],
growth cone [GO:0030426],
macromolecular complex [GO:0032991],
cell projection [GO:0042995],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
intracellular membrane-bounded organelle [GO:0043231],
membrane raft [GO:0045121],
synapse [GO:0045202],
glutamatergic synapse [GO:0098978],